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> 师资队伍 > 特聘教授

黄玉辉

【日期:2014-10-9 16:08:21】 【人气:608】  【关 闭】  【打 印

苏州大学唐仲英血液学研究中心(703号楼507室)

电话:86-512-658808773507

传真:86-512-65880929

Email: huangyh@suda.edu.cn

研究领域及内容:

肿瘤免疫微环境和免疫治疗

肿瘤在我国的发生率和死亡率正逐年上升,而传统的化疗和放疗往往仅能短暂延长病人的寿命。近年来在肿瘤免疫治疗上的进展为治愈恶性肿瘤带来了一丝曙光。目前,肿瘤免疫治疗面临的一大障碍是异常的肿瘤血管和免疫抑制性的肿瘤微环境。它们不仅阻碍抗肿瘤有效成分的输送,而且也抑制了它们的活性和导致了抗药性。我的实验室将致力于研究肿瘤免疫微环境的特性及形成机理,解析肿瘤与免疫系统之间的相互作用机制,并通过融合肿瘤免疫学、肿瘤血管控制、生物靶标和纳米技术等来发展高效特异的肿瘤靶向免疫治疗方略。

近五年代表性成果:

1.       Huang Y, Harnessing the immune system to cure cancer. Transl Cancer Res, 3(3): E1-E4, 2014.

2.       Huang Y, Goel S, Duda DG, Fukumura D, Jain RK*. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res, 73: 2943-8, 2013.

3.       Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK*, Poznansky MC. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A 109: 17561-6, 2012.

4.       Huang Y, Snuderl M, Jain RK*. Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity. Cancer Cell 19: 1-2, 2011.

5.       Huang Y, Lin L, Shanker A, Malhotra A, Yang L, Dikov MM, Carbone DP*. Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth. Cancer Res 71: 6122-31, 2011.

6.       Huang Y, Chen X, Dikov MM, Novitskiy SV, Mosse CA, Yang L, Carbone DP*. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 110: 624-31, 2007.

7.       Snuderl M1, Batista A1, Kirkpatrick ND1, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK*. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152: 1065-76, 2013.

8.       Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG*. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology 59: 1435-47, 2014.

9.       Hiratsuka S1, Duda DG1, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK*. C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proc Natl Acad Sci U S A 108: 302-7, 2011.

10.    Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK*. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst 105: 1188-201, 2013.

11.    Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, Dietrich J, Stemmer-Rachamimov AO, Batchelor TT, Jain RK*. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro Oncol 15: 1079-87, 2013.

12.    Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK*. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci U S A 109: E3119-27, 2012.

13.    Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP*. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A 108: 18784-9, 2011.

14.    Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG*. Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Res 70: 5679-85, 2010.

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