题目：Polymer Nanoparticles for Molecular Imaging
摘要：The biological application of polymeric nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of human cancers. We have prepared self-assembled polymeric nanoparticles for theragnostic imaging of tumors. Near-infrared fluorescent-labeled polymeric nanoparticles visualized the accumulation of polymeric nanoparticles at tumor sites. By using NIR polymeric nanoparticles, the frequencies of drug treatment, therapeutic efficacies of polymeric macromolecular drugs could be evaluated.
报告人：
韩国科学技术研究院(Korea Institute of Science and Technology, KIST)生物医学研究中心主任。
首尔大学工学部获得学士学位(1982年)和硕士学位(1984年)，美国犹他大学药学院获得博士学位(1993年, 指导教授: Sung Wan Kim博士)，犹他大学控释给药研究中心博士后，1994年加盟KIST。主要研究方向为生物高分子材料与给药系统。
时间：
地点：独墅湖校区炳麟图书馆825会议室
近三年部分主要研究论文目录（通讯作者）：
1. Jae Hyung Park, Seulki Lee, Jong-Ho Kim, Kyeongsoon Park, Kwangmeyung Kim, Ick Chan Kwon, Polymeric nanomedicine for cancer therapy, Progress in Polymer Science, Volume 33, Issue 1, January 2008, Pages 113-137. (IF: 14.818)
2. Jong-Ho Kim, Kyeongsoon Park, Hae Yun Nam, Seulki Lee, Kwangmeyung Kim, Ick Chan Kwon, Polymers for bioimaging, Progress in Polymer Science, 32 (2007) 1031–1053. (IF: 14.818)
3. Min KH, Park K, Kim YS, Bae SM, Lee S, Jo HG, Park RW, Kim IS, Jeong SY, Kim K, Kwon IC., Hydrophobically modified glycol chitosan nanoparticles- encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy.J Control Release. 2008 May 8;127(3):208-18. (IF: 4.012)
4. Lee S, Cha EJ, Park K, Lee SY, Hong JK, Sun IC, Kim SY, Choi K, Kwon IC, Kim K, Ahn CH., A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination., Angew Chem Int Ed Engl. 2008;47(15):2804-7. (IF: 10.232)
5. Kim JH, Kim YS, Park K, Lee S, Nam HY, Min KH, Jo HG, Park JH, Choi K, Jeong SY, Park RW, Kim IS, Kim K, Kwon IC., Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice.J Control Release. 2008 Apr 7;127(1):41-9. Epub 2007 Dec 26. (IF: 4.012)
6. Ko J, Park K, Kim YS, Kim MS, Han JK, Kim K, Park RW, Kim IS, Song HK, Lee DS, Kwon IC., Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.J Control Release. 2007 Nov 6; 123(2):109-15. (IF: 4.012)
7. Park K, Kim JH, Nam YS, Lee S, Nam HY, Kim K, Park JH, Kim IS, Choi K, Kim SY, Kwon IC., Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles., J Control Release. 2007 Oct 8;122(3):305-14. Epub 2007 Apr 19. (IF: 4.012)
8. Kim JH, Lee S, Park K, Nam HY, Jang SY, Youn I, Kim K, Jeon H, Park RW, Kim IS, Choi K, Kwon IC. Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells. Angew Chem Int Ed Engl. 2007; 46(30):5779-82. (IF: 10.232)
9. Na K, Kim S, Park K, Kim K, Woo DG, Kwon IC, Chung HM, Park KH.Heparin/poly(l-lysine) nanoparticle-coated polymeric microspheres for stem-cell therapy., J Am Chem Soc. 2007 May 9;129(18):5788-9. (IF: 7.696)
10.Kim JH, Lee S, Kim K, Jeon H, Park RW, Kim IS, Choi K, Kwon IC.Polymeric nanoparticles for protein kinase activity., Chem Commun (Camb). 2007 Apr 7;(13):1346-8. (IF: 4.521)
11.Kim K, Lee M, Park H, Kim JH, Kim S, Chung H, Choi K, Kim IS, Seong BL, Kwon IC. Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. J Am Chem Soc. 2006 Mar 22;128(11):3490-1. (IF:7.696)
12.Kim JH, Kim YS, Kim S, Park JH, Kim K, Choi K, Chung H, Jeong SY, Park RW, Kim IS, Kwon IC., Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel., J Control Release. 2006 Mar 10;111(1-2):228-34. (IF: 4.012)
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