题目1:Carbon monoxide, hemin and hypertension
报告人:王睿教授
1990年加拿大埃德蒙顿省艾伯塔大学(生理学)博士学位;1997-2001年加拿大斯喀彻温省萨斯卡通大学生理学副教授,2001-2006年加拿大斯喀彻温省萨斯卡通大学生理学教授;2003-2004年加拿大斯喀彻温省萨斯卡通大学心血管研究室主任;2004年至今加拿大安大略省雷湾市Lakehead大学生物学部教授,研究室副主任。2005年西安第四军医大学名誉教授;2007年上海复旦大学长江学者。
研究领域:
高血压、血管粥样硬化等心血管疾病的发病机制及药物治疗。
Professor Wang will show their study data that representing a breakthrough in searching for a long-lasting remedy for hypertension management.
PUBLICATIONS(SELECTED)
- Yang G, Yang W, Wu L, and Wang R. H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J. Biol. Chem. 282 (22): 16567–16576, 2007 (IF, 6.5)
- Wang R, Shamloul R, Wang X, Meng Q, and Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension. 48:685-692, 2006. (IF, 5.6)
- Wu L, Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 57:585-630, 2005. (IF, 27.1)
- Yang G, Cao K, Wang R. Cystathionine g-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. J. Biol. Chem. 279: 49199-49205, 2004. (IF, 6.5)
- Yang G, Sun X, Wang R. Hydrogen Sulfide-induced Apoptosis of Human Aorta Smooth Muscle Cells via the Activation of MAP Kinases and Caspase-3. FASEB J. 18:1782-1784, 2004. (IF, 7.2)
- Wu L, Noyan Ashraf MH, Wang R, Paterson PG, Ferrie A, Juurlink BHJ. Dietary phase 2 enzyme inducer and its cardiovascular protective effect in stroke prone SHR. Proc. Natl. Acad. Sci. USA. 101:7094-7099, 2004. (IF, 10.3)
- Ndisang JF, Wu L, Zhao W and Wang R. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 101: 3893-3900, 2003. (IF, 10.3)
题目2:The role of methylglyoxal in insulin resistance syndrome
报告人:吴凌云教授
1978-1982年山东医科大学医学硕士学位;1989-1991年加拿大Alberta大学理学硕士学位(生理学);1998-1999年,加拿大de Montréal大学哲学博士学位(医药学);1999-2002年,加拿大Saskatchewan大学攻读博士后; 2002-2004年,加拿大Saskatchewan大学药学院药理学部门任助理教授;2004-2007年任副教授;2007年7月后任教授。
研究领域:
高血压发病机制及药物治疗。
Dr.Wu’s studies indicate that abnormal methylglyoxal metabolism may be a pathogenic factor in the development of insulin resistance syndrome, including diabetes, obesity, and hypertension.
PUBLICATIONS(SELECTED)
- Wang X, Jia X, Chang T, Desai, K, Wu L: Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats. J. Hypertens, 26:765-772, 2008. (IF: 5.5)
- Yang G, Yang W, Wu L, Wang R. H2S, endoplasmic reticulum stress, and apoptosis of Insulin-secreting Beta Cells., Apr 12; [Epub ahead of print] PMID: 17430888. J. Biol. Chem 1;282(22):16567-76, 2007. (IF: 7.6)
- Jia X, Olson D, Ross A, Wu L. Structural and functional changes in human insulin induced by methylglyoxal. FASEB J. 20(9):1555-1557, 2006. Epub 2006 May 24 (IF: 7.2).
- Yang G, Wu L, Wang R. Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells. FASEB J. 20(3):553-5, 2006. (IF: 7.2).
- Wang X, Desai K, Juurlink BHJ, de Champlain J, Wu L. Gender-related differences in advanced glycation endproducts, oxidative stress makers and nitric oxide synthases in rats. Kidney Int. 69: 281-287, 2006 (IF: 5.3).
- Wang R, Shamloul R, Wang X, Meng QH, Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension, 48(4):685-92, 2006. (IF: 6.3)
- Wu L, Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 57(4): 585-630, 2005 (IF: 27.0).
地点:苏州大学独墅湖校区炳麟图书馆825会议室
时间:2008年6月27日下午 2:30
苏州大学医学部
围产医学生物学研究室
衰老与神经疾病研究室
(科研办公室)

