医学部系列学术讲座之七

发布者:系统管理员发布时间:2008-06-23浏览次数:1712


题目1Carbon monoxide, hemin and hypertension

报告人王睿教授

1990加拿大埃德蒙顿省艾伯塔大学生理学)博士学位;1997-2001加拿大斯喀彻温省萨斯卡通大学生理学副教授,2001-2006加拿大斯喀彻温省萨斯卡通大学生理学教授;2003-2004加拿大斯喀彻温省萨斯卡通大学心血管研究室主任;2004至今加拿大安大略省雷湾市Lakehead大学生物学部教授,研究室副主任。2005年西安第四军医大学名誉教授;2007上海复旦大学长江学者

研究领域:

高血压、血管粥样硬化等心血管疾病的发病机制及药物治疗

Professor Wang will show their study data that representing a breakthrough in searching for a long-lasting remedy for hypertension management.

PUBLICATIONSSELECTED

  1. Yang G, Yang W, Wu L, and Wang R. H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J. Biol. Chem. 282 (22): 16567–16576, 2007 (IF, 6.5)
  2. Wang R, Shamloul R, Wang X, Meng Q, and Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension. 48:685-692, 2006. (IF, 5.6)
  3. Wu L, Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 57:585-630, 2005. (IF, 27.1)
  4. Yang G, Cao K, Wang R. Cystathionine g-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. J. Biol. Chem. 279: 49199-49205, 2004. (IF, 6.5)
  5. Yang G, Sun X, Wang R. Hydrogen Sulfide-induced Apoptosis of Human Aorta Smooth Muscle Cells via the Activation of MAP Kinases and Caspase-3. FASEB J. 18:1782-1784, 2004. (IF, 7.2)
  6. Wu L, Noyan Ashraf MH, Wang R, Paterson PG, Ferrie A, Juurlink BHJ. Dietary phase 2 enzyme inducer and its cardiovascular protective effect in stroke prone SHR. Proc. Natl. Acad. Sci. USA. 101:7094-7099, 2004. (IF, 10.3)
  7. Ndisang JF, Wu L, Zhao W and Wang R. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 101: 3893-3900, 2003. (IF, 10.3)

题目2The role of methylglyoxal in insulin resistance syndrome

报告人吴凌云教授

1978-1982年山东医科大学医学学位;1989-1991年加拿大Alberta大学理学硕士学位(生理学)1998-1999加拿大de Montréal大学哲学博士学位医药学);1999-2002加拿大Saskatchewan大学攻读博士后; 2002-2004加拿大Saskatchewan大学药学院药理学部门任助理教授;2004-2007年任副教授;20077月后任教授。

研究领域:

高血压发病机制及药物治疗

Dr.Wu’s studies indicate that abnormal methylglyoxal metabolism may be a pathogenic factor in the development of insulin resistance syndrome, including diabetes, obesity, and hypertension.

PUBLICATIONSSELECTED

  1. Wang X, Jia X, Chang T, Desai, K, Wu L: Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats. J. Hypertens, 26:765-772, 2008. (IF: 5.5)
  2. Yang G, Yang W, Wu L, Wang R. H2S, endoplasmic reticulum stress, and apoptosis of Insulin-secreting Beta Cells., Apr 12; [Epub ahead of print] PMID: 17430888. J. Biol. Chem 1;282(22):16567-76, 2007. (IF: 7.6)
  3. Jia X, Olson D, Ross A, Wu L. Structural and functional changes in human insulin induced by methylglyoxal. FASEB J. 20(9):1555-1557, 2006. Epub 2006 May 24 (IF: 7.2).
  4. Yang G, Wu L, Wang R. Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells. FASEB J. 20(3):553-5, 2006. (IF: 7.2).
  5. Wang X, Desai K, Juurlink BHJ, de Champlain J, Wu L. Gender-related differences in advanced glycation endproducts, oxidative stress makers and nitric oxide synthases in rats. Kidney Int. 69: 281-287, 2006 (IF: 5.3).
  6. Wang R, Shamloul R, Wang X, Meng QH, Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension, 48(4):685-92, 2006. (IF: 6.3)
  7. Wu L, Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 57(4): 585-630, 2005 (IF: 27.0).

地点:苏州大学独墅湖校区炳麟图书馆825会议室

时间:2008年6月27日下午 2:30

苏州大学医学部

围产医学生物学研究室

衰老与神经疾病研究室

(科研办公室)