医学部系列学术讲座之八

题目：Activation of Stem cells in the Hippocampus

报告人：Professor Perry F. BARTLETT

Professor, Chair of Molecular Neuroscience，The University of Queensland

ARC Federation Fellow，Director, Queensland Brain Institute, UQ

FAA (Fellow of the Australian Academy of Science) 澳大利亚科学院院士

时间：2008.07.02（周三）下午14：00

地点：独墅湖校区炳麟图书馆720会议室

报告人简介：

As a neuroscientist, Professor Bartlett’s primary goal remains focused on understanding how neural stem cells regulate brain development and function, as well as defining the mechanisms by which this endogenous stem cell population can be directed toward the production of new neurons to replace those lost following disease or damage in the adult brain.

In 2001, his laboratory's work verifying the existence of adult brain stem cells was featured on the front cover of the prestigious journal, Nature. In October 2002, Professor Bartlett and colleagues in Melbourne made a world-first discovery of a mechanism that may stimulate the production of new nerve cells in the brain. The Bartlett-led team showed, for the first time, how stem cells in the brain were responsible for the production of new nerve cells, opening up a whole new field of discovery in this area. Stimulating the production of new nerve cells in the brain, offers the hope that normal brain function – such as memory formation – can one day be enhanced. It could also allow for the replacement of nerve cells lost because of a stroke, trauma or neurodegenerative ailments such as Alzheimer's Disease, Parkinson's Disease or Motor Neuron Disease.

In 2004, Professor Bartlett and his colleagues spear-headed another major discovery. This was a molecule that blocked regrowth of damaged nerve processes … a much-needed source of inspiration for people suffering from spinal cord injury. It is envisaged that success in these areas will revolutionize the treatment of such conditions over the next 10 years.

Professor Bartlett regularly receives invitations to present keynote talks at the foremost scientific forums and his work has been extensively published in reputable journals. He is internationally renowned in the field of cellular and molecular neuroscience, a fact highlighted by his election as a Fellow of the Australian Academy of Science (FAA) and the awarding of an Australian Research Council Federation Fellowship.

PUBLICATIONS（SELECTED）

1、Rietze RL, Bartlett PF (2003) Regulation of endogenous stem cells in the adult mammalian brain: promoting neural repair. In: Handbook of Cell Signaling Volume 3 (eds R Bradshaw and E Dennis) San Diego: Elsevier Science, pp. 625-634.

2、Coulson EJ, Reid K, Shipham KM, Morley S, Kilpatrick TJ, Bartlett PF (2004) The role of neurotransmission and the Chopper domain in p75NTR death signaling. Progress in Brain Research: NGF and related molecules in health and disease 146: 41-62.

3、Bull ND, Bartlett PF (2005) The adult mouse hippocampal progenitor is neurogenic but not a stem cell. Journal of Neuroscience 25: 10815-10821.

4、Young KM, Merson TD, Sotthibundhu A, Coulson EJ, Bartlett PF (2007) p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. Journal of Neuroscience 27: 5146-5155.

5、 Morley SM, Power JM, Coulson EJ, Bartlett PF (2007) Zinc toxicity is dependent on Trk activation Experimental Neurology 205: 360-366.

6、Nandam LS, Jhaveri D, Bartlett PF (2007) 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression. Clinical and Experimental Pharmacology and Physiology 34: 546-551.

7、Walker TL, Yasuda T, Adams DJ, Bartlett PF (2007) The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells. Journal of Neuroscience 27: 3734-3742.

8、Walker TL,White A, Black DM, Wallace RH, Sah P, Bartlett PF (2008) Latent stem and progenitor cells in the hippocampus are activated by neural excitation. Journal of Neuroscience 28: 5240-5247. (front cover)