(Time Interval Measuring Enzyme)
报告人：Dr. Hidenori KAI
鳥取大学 大学院 生物資源科学専攻?（元）教授
Department of Biotic Resources and Environment Science,
Faculty of Agriculture,
时间：2008.07.17（星期四）上午9：00-11：00
地点：苏州大学独墅湖校区703号楼3楼会议室（3331室）
欢迎广大师生踊跃参加！
报告人简介
Hidenori KAI（甲斐英則）博士。毕业于日本名古屋大学大学院，留学美国华盛顿大学。先后任教于日本国立名古屋大学和鸟取大学，为鸟取大学生物资源学科教授。一直致力于研究胚胎发生和分化的生物钟分子调控机理。在国际上率先提出了不依赖基因表达，依靠蛋白质空间结构变化计量环境温度的蛋白质生物钟模式，突破了依靠神经（激素）反应或基因表达、反馈光照节律的传统生物钟分子调控理论，建立了蛋白质对环境温度节律反应的全新机制。
MAJOR RESEARCH PROJECT
1. The Molecular Mechanism of a Time Interval Measuring Enzyme
2. Interaction of Peptide and Protein
3. Protein Structure and Function of the Formation Mechanism of Expression
PUBLICATIONS（SELECTED）
1. The Molecular Mechanism of the Termination of Insect Diapause, Part 1: A Timer Protein, TIME-EA4, in the Diapause Eggs of the Silkworm Bombyx mori is a Metallo-Glycoprotein. Chembiochem, 7(10): 1590-1598, 2006.
2. Time-measurement-regulating peptide PIN may alter a timer conformation of time interval measuring enzyme (TIME). Journal of Insect Physiology, 52:461-467, 2006.
3. The peptide PIN changes the timing of transitory burst activation of timer-ATPase TIME in accordance with diapause development in eggs of the silkworm, Bombyx mori. Journal of Insect Physiology, 51, 1025-1032, 2005.
4. Structure of pentasaccharide of glycopeptide from TIME-EA4, N-glycoprotein in silkworm diapause eggs. Bioorganic & Medicinal Chemistry, 14, 2527-2531, 2004.
5. Demarcation of diapause development by cold and its relation to time-interval activation of TIME-ATPase in eggs of the silkworm, Bombyx mori. Journal of Insect Pysiology 50, 1053-1064, 2004.
6. Interval timer protein TIME, screw with a PIN. CHRONOBIOLOGY, 10:28-34, 2004（In Japanese）.
7. Determination of a sugar chain and its linkage site on a glycoprotein TIME-EA4 from silkworm diapause eggs by means of LC-ESI-Q-TOF-MS and MS/MS. Bioorganic and Medicinal Chemistry, 10(6): 1703-1710(8) 2002
8. Carbohydrate moiety of Time Interval Measuring Enzyme regulates the time through its interaction with time-holding peptide PIN. J Biochem, 129, 221-227, 2001
9. Accomplishment of time-interval activation of esterase A4 by simple removal of PIN fraction. Chronobiology International, 16, 51-58, 1999.
(科研办公室)
