题 目：微型RNA在癌症与血液分化中的作用
报告人：Jun Lu, Ph.D.
Assistant Professor
时 间：2008.09.19（星期五）上午10：00
地 点：苏州大学独墅湖校区炳麟图书馆712会议室
报告人简介：
Education：
1997-2003 Ph.D. Degree in Biochemistry
Department of Biochemistry
Advisor: Dr. Katya Ravid
1993-1997 Bachelor’s Degree of Science, with Honor
Departments of Intensive Instruction and Biochemistry
Professional Experience：
2008- Assistant Professor
2004-2008 Postdoctoral Associate, Broad Institute of MIT and Harvard
Postdoctoral Associate, Dana-Farber Cancer Institute
Publications
1、Yu-Fen Chou, Hsu-Hsin Chen, Maureen Eijpe, Akiko Yabuuchi, Joshua G. Chenoweth, Jun Lu, Ronald D.G. McKay and Niels Geijsen. Blastocyst-derived Stem Cells Reveal an Active Role for Growth Factor Signaling in the Induction of Stem Cell Pluripotency. Cell, 2008, In Press
2、Jun Lu, Shangqin Guo, Benjamin L. Ebert, Hao Zhang, Xiao Peng, Jocelyn Bosco, Jennifer Pretz, Rita Schlanger, Judy H. Wang, Raymond H. Mak, David M. Dombkowski, Frederic I. Preffer, David T. Scadden and Todd R. Golub. microRNA-mediated control of of cell fate in megakaryocyte-erythrocyte progenitors. Developmental Cell, 2008, 14(6):843-53
3、Tatsuya Kobayashi, Jun Lu, Bradley Cobb, Matthias Merkenschlager, Andrew P. McMahon and Henry M. Kronenberg. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. PNAS, 2008, 105(6):1949-54
4、Shuangli Mi, Jun Lu (co-first author), Miao Sun, Zejuan Li, Hao Zhang, Mary Beth Neilly, Yungui Wang, Zhijian Qian, Jie Jin, Yanming Zhang, Stefan K. Bohlander, Michelle M. LeBeau, Richard A. Larson, Todd R. Golub, Janet D. Rowley and Jianjun Chen. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. PNAS, 2007, 104(50):19971-6
5、Sadakatsu Ikeda, Sek Won Kong, Jun Lu, Egbert Bisping, Hao Zhang, Paul D. Allen, Todd R. Golub, Burkert Pieske, and William T. Pu. Altered miRNA expression in human heart disease. Physiological Genomics, 2007 (Epub ahead of print)
6、Madhu S. Kumar, Jun Lu, Kim L. Mercer, Todd R. Golub and
7、Yehonathan Hazony, Jun Lu, Cynthia St.Hilaire and Katya Ravid. Hematopoietic Gene Promoters Subjected to a Group-Combinatorial Study of DNA Samples: Identification of a Megakaryocytic Selective DNA Signature. Nucleic Acids Research,2006, 34(16):4416-28
8、Shangqin Guo, Jun Lu, Aravind Subramanian and Gail E. Sonenshein. Microarray assisted pathway analysis identifies MAPK signaling as a mediator of resistance to the green tea polyphenol epigallocatechin 3-gallate in Her-2/neu overexpressing breast cancer cells. Cancer Research, 2006, 66(10):5322-9
9、Jun Lu, Gad Getz, Eric A. Miska, Ezequiel A. Alvarez-Saavedra, Justin Lamb, David Peck, Alejandro Sweet-Cordero, Benjamin L. Ebert, Raymond H. Mak, Adolfo A. Ferrando, James R. Downing, Tyler Jacks, H. Robert Horvitz and Todd R. Golub. MicroRNA expression profiles classify human cancers. Nature, 2005, 435(7043):834-8
10、Xiaohui Xie, Jun Lu, E. J. Kulbokas, Todd R. Golub, Vamsi Mootha, Kerstin Lindblad-Toh, Eric S. Lander and Manolis Kellis. Systematic discovery of regulatory motifs in human promoters and 3’ UTRs by comparison of several mammals. Nature, 2005, 434 (7031):338-45
11、Jun Lu, Michael Pazin and Katya Ravid. Properties of Ets-1 binding to chromatin and its effect on platelet factor four gene expression. Molecular and Cellular Biology, 2004, 24(1):428-41
12、Jun Lu, Anne Pierron and Katya Ravid. An adenosine analog, IB-MECA, downregulates estrogen receptor a and suppresses human breast cancer cell growth. Cancer Research, 2003, 63(19):6413-23
13、Katya Ravid, Jun Lu, Jeff Zimmet and Mathew Jones. A road to ploidy: the megakaryocyte example. Journal of Cellular Physiology, 2002, 190:7-20
14、Yulia Kaluzhny, Beatrice Hechler, Jun Lu, Hao Nguyen, Leah Cataldo and Katya Ravid. A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation. FEBS Letters, 2002, 527(1-3): 279-83
15、Zhengyu Wang, Ying Zhang, Jun Lu, Shishinn Sun, and Katya Ravid. Mpl ligand enhances the transcription of the cyclin D3 gene: A potential role for Sp1 transcription factor. Blood, 1999, 93(12):4208-4221
16、Leah M. Cataldo, Ying Zhang, Jun Lu, and Katya Ravid. Rat NAP1: cDNA cloning and upregulation by Mpl ligand. Gene, 1999, 226(2):355-364
(科研办公室)
