学术报告

题目 ：Regulation of MUC1 function by γ-secretase mediated cleavage and intracellular trafficking

报告人：袁正隆 博士

1999-2001 Lecturer, Department of Immunology, Second Military Medical University, Shanghai, China

2001-2002 Research Scientist, Shanghai Genomics Ltd. Pu Dong, Shanghai, China

2002-2003 Department of Pathology and Lab medicine, Brown University

2003-2007 Research Associate, Department of Surgery, Brown University

2007-present Instructor, Department of Surgery, Brown University

代表性论文

1. Yuan Z, Liu X, Chung MA. γ-secretase mediated Muc1 cleavage is important for cell proliferation. In revision(J Biol Chem )

2. Nie Y, Erion DM , Yuan Z, Dietrich M, Shulman G,4, Horvath T, Gao Q. Sirt1 downregulates STAT3 function in inhibition of gluconeogenesis. In revision(Nature)

3. Liu X, Yuan Z, Chung MA. EGF mediate MUC1 cytoplasmic translocation is Rab5-dependent. Biochem Biophys Res Commun In press

4. Yuan Z, Liu X, Wong S, Machan J, Chung MA. Muc1 plays a key role in pancreatic cancer growth. J Surg Res In press

5. Yuan Z, Wong S, Borrelli A, Chung MA. Down-regulation of MUC1 in cancer cells inhibits cell migration by promoting E-cadherin/catenin complex formation. Biochem Biophys Res Commun. 2007 Oct 6; 362(3):740-6.
6. Tang X, Gao JS, Guan YJ, McLane KE, Yuan ZL, Ramratnam B, Chin YE. Acetylation-dependent signal transduction for type I interferon receptor. Cell. 2007 Oct 5; 131(1):93-105.

7.      Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE. Ankyrin repeat and SOCS Box 3(ASB3) mediates ubiquitination and degradation of TNF Recepter-II. Mol Cell Biol,  2005 Jun;25(11):4716-26

8.      Yuan ZL, Guan YJ, Chatterjee D, Chin YE. Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue. Science. 2005 Jan 14; 307(5707): 269-273. 

9.      Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol. 2004 Nov; 24(21):9390-400. 

10.  Ivanov SS, Chung AS, Yuan ZL, Guan YJ, Sachs KV, Reichner JS, Chin YE. Antibodies immobilized as arrays to profile protein post-translational modifications in mammalian cells. Mol Cell Proteomics. 2004 Aug; 3(8):788-95. 

地点：苏州大学703号楼3331会议室

时间：2008年10月27号下午二点

苏州大学医学部

基础医学与生物科学学院