学术报告（基础医学与生物科学学院）

题目 ：Cutting Edge Immunology Research

报告人：王德民 教授

Investigator (Associate professor), Blood Research Institute, Milwaukee, WI, USA

地点：苏州大学独墅湖新校区炳麟图书馆825会议室

时间：2008年11月7日（周五）上午10点

报告人介绍：

Dr. Demin Wang received his bachelor degree from Nanjing University in 1988 and Ph.D. from University of Tennessee in 1995. He is currently an associate professor at Blood Research Institute in Wisconsin. He is a well known researcher in the field of cytokine and B cell receptor signaling and published numerous papers in the leading journals of the field. He will introduce the cutting edge immunology research, which will benefit our graduate students and young teachers. Please make effort to attend.

PUBLICATIONS (after 2005)

1. Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell 7:87-99, 2005.

2. Regunathan J, Chen Y, Wang D and Malarkannan S. NKG2D-mediated NK cell cytotoxicity is regulated by Inhibitory Ly49 Receptors. Blood 105:233-240, 2005.

3. Zhu M, Granillo O, Wen R, Yang K, Dai X, Wang D and Zhang W. Negative regulation of lymphocyte activation by the adaptor protein LAX. J. Immunol. 174: 5612 – 5619, 2005.

4. Mutsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D and Lin X. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation. Immunity 23:575-585, 2005.

5. Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R and Wang D. Distinct roles of PI3K and PLCg2 in B cell receptor-mediated signal transduction. Mol. Cell. Biol. 26:88-99, 2006.

6. Cheeseman KL, Kashiwagi K, Michaud T, Ueyama T, Wang D, Flax LA, Shirai Y, Loegering DJ, Saito N and Lennartz MR. Targeting of PKC-ε during FcγR-dependent phagocytosis requires the εC1B domain and phospholipase C-γ1. Mol. Biol. Cell. 17:799-813, 2006.

7. Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM and Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B-cells. Blood 107: 4407-4416, 2006.

8. Chen Y, Dai X, Haas AL, Wen R and Wang D. Proteasome-dependent down-regulation of activated Stat5A in the nucleus. Blood 108:566-574, 2006.

9. Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D* and Malarkannan S*. Differential and non-redundant roles of PLCγ2 and PLCγ1 in the terminal maturation of NK cells1. J. Immunol. 177:5365-5376, 2006. *equal senior authorship

10. Hoek KL, Antony P, Lowe J, Shinners N, Sarmah B, Wente SR, Wang D, Gerstein RM and Khan WN. Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. J. Immunol. 177:5405-5413, 2006.

11. Wen R, Chen Y, Fu G, Schuman J, Yang C, Stephan RP, Cleveland JL and Wang D. An essential role of phospholipase Cg2 in early B cell development and Myc-mediated lymphomagenesis. Mol. Cell. Biol. 26: 9364–9376, 2006.

12. Chen Y, Pappu B, Zeng H, Xue L, Morris SW, Lin X, Wen R and Wang D. Bcl10 is essential for FceR-mediated degranulation and IL-6 production in mast cells. J. Immunol. 178:49-57, 2007.

13. Blonska M, Pappu B, Matsumoto R, Li H, Su B, Wang D and Lin X. The CARMA1-Bcl10 complex selectively regulates JNK2 in the T cell receptor signaling pathway. Immunity 26:55-66, 2007.

14. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, and Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282:9358-9363, 2007.

15. Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C and Krensky AM. KLF13 regulates T lymphocyte survival in vivo. J. Immunol. 178:5496-5504, 2007.

16. Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M and Budd RC. Caspase-8 and c-FLIPL associate in lipid rafts with NF-kB adaptors during T cell activation. J. Biol. Chem. 282:19365-19374, 2007.

17. Dai X, Chen Y, Di L, Podd A, Li G, Bunting KD, Hennighausen L, Wen R and Wang D. Stat5 is essential for early B cell development but not for B cell maturation and function. J. Immunol. 179:1068-1079, 2007.

18. Bai L, Chen Y, He Y, Dai X, Lin X, Wen R and Wang D. Phospholipase Cg2 contributes to light chain gene activation and receptor editing. Mol. Cell. Biol. 27:5957-5967, 2007.

19. Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R and Wang D. Bcl10 plays a pivotal role in NK cell-mediated cytotoxicity and cytokine generation. J. Immunol. 179: 3752-3762, 2007.

20. Shinners NP, Carlesso G, Castro I, Hoek K, Corn R, Woodland R, Scott ML, Wang D and Khan WN. Bruton’s tyrosine kinase mediates NF-kB activation and B cell survival by B cell activating factor of the TNF family. J. Immunol. 179: 3872-3880, 2007.

21. Li G, Wang Z, Zhang Y, Couldrey C, Haviernikova E, Cui Y, Hennighausen L, Moriggl R, Wang D, Tse W and Bunting KD. The STAT5 N-domain is differentially required for hematopoietic cell growth,survival, and migration. Exp. Hematol. 35: 1684-1694, 2007.

22. Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, and Wang D. A critical role of Rap1b in B cell trafficking and marginal zone B cell development. Blood 111: 4627-4636, 2008.

23. Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, et al. Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking gimap5. (Blood in press)

24. Zeng H, Chen Y, Yu M, Xue L, Gao X, Morris SW, Wang D, and Wen R. TCR-mediated activation of CD4+CD44hi T cells bypasses Bcl10. (J. Biol. Chem. in press)

25. Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michaelek S, He Y, Yu M, Fu YX, Wen R, Wu H and Wang D. Phospholipase Cγ2 mediates RANKL-stimulated lymph-node organogenesis and osteoclastogenesis. (J. Biol. Chem. in press)