医学部系列学术讲座之二十

题目：TGF-BETA SIGNALING PATHWAY

报告人：PING DAI（戴平）博士

Department of  Pathology and CellRegulation
GraduateSchool of Medicine
Kyoto Prefectural University of Medicine

时间：2008.11.6（星期四）下午14：00-16：00

地点：苏州大学独墅湖校区炳麟图书馆712会议室

报告人简介：

戴平博士1982、1990先后就读于苏州大学与浙江大学，1994年获得东京农工大学连合大学院博士学位。1994年至2004年，先后在日本理化学研究所分子遗传学研究室任共同研究员、基础科学特别研究员、日本科学技术振兴事业团CREST 研究员等，现任教京都府立医科大学大学院医学研究科细胞分子机能病理学研究室，该团队主要研究课题是心肌梗塞及不整脉的细胞分子机能病理学。戴平博士的重点研究内容是发生、细胞增殖、发病及分化相关的TGF-beta signaling pathway。

1.Dai, P., Nakagami, T., Tanaka, H., Hitomi, T., & Takamatsu, T: Cx43 mediates TGF-β signaling through competitive Smads binding to microtubules. Mol. Biol. Cell,18, 2264-2273 (2007). (Corresponding author)（IF=7.16）

2.Dai, P., Akimaru, H., & Ishii, S: A hedgehog-responsive region in theDrosophila wing disc is defined by Debra-mediated ubiquitination and lysosomal degradation of Ci. Dev. Cell,4, 917-928 (2003).（IF=14.6）(Selected as a featured article)

3.Dai, P., Shinagawa, T., Nomura, T., Harada, J., Kaul, SC., Wadhwa, R., Khan, MM.Akimaru, H., Sasaki, H., Colmenares, C., & Ishii, S: Ski is involved in transcriptional regulation by the repressor and full-length form of Gli3. Genes Dev., 16, 2843-2848 (2002).(IF=14.795)

4.Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M., & Ishii, S: Sonic hedgehog-induced activation of Gli1 promotor mediated by GLI3. J. Biol. Chem., 274, 8143-8152 (1999).( IF=6.23)

5.Dai, P., Akimaru, H., Tanaka, Y., Hou, D.-X., Yasukawa, T., Kanei-Ishii, C.,Takahashi, T., & Ishii, S: CBP as a transcriptional coactivator of c-Myb. Genes Dev., 10, 528-540 (1996). (IF=14.795)

6.Nakagami, T., Tanaka, H., Dai, P., Tanabe, T., Mani, H., Fujiwara, K., Lin, SF.,Matsubara, H., & Takamatsu, T: Generation of reentrant arrhythmias by dominant-negative inhibition of connexin 43 in rat cultured cardiomyocyte monolayers. Cardiovasc. Res., 79, 70-79 (2008).（IF=5.28）

7.Harada, Y., Ota, T., Dai, P., Yamaoka, Y., Hamada, K., Fujita, K., & Takamatsu, T: Imaging of anticancer agent distribution by a slit-scanning Ramanmicroscope. Proc. SPIE,in press

8.Nakano, Y., Oyamada, M., Dai, P., Nakagami, T., Kinoshita, S., & Takamatsu, T: Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo. Invest. Ophthalmol. Vis. Sci.,49, 93-104 (2008). （IF=4.148）

9.Yamamoto, Y., Shiraishi, I., Dai, P., Hamaoka, K., &Takamatsu, T: Regulation of embryonic lung vascular development by vascular endothelial growth factor receptors, Flk-1 and Flt-1. Anat. Rec., (Hoboken) 290, 958-973 (2007). (IF=1.801)

10.Tanabe, T., Oyamada, M., Fujita, K., Dai, P., Tanaka, H., & Takamatsu, T:Multiphoton excitation-evoked chromophore-assisted laser inactivation using green fluorescent protein. Nat. Methods, 2,503-505 (2005).（IF=6.741）

11.Takahashi, T., Suwabe, N., Dai, P., Yamamoto, M., Ishii, S., & Nakano, T: Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP. Oncogene, 19, 134-140 (2000). .(IF=6.582)

12.Sano, Y., Tokito, F., Dai, P., Yamamoto, T., & Ishii, S: CBP alleviates the intramolecular inhibiton of ATF-2 function. J. Biol. Chem., 273, 29098-29105 (1998). ( IF=5.79)

13.Akimaru, H., Chen, Y.,Dai, P., Hou, D.-X., Nonaka, M., Smolik, S.M.,Armstrong, S., Goodman, R., & Ishii, S: Drosophila CBP is a co-activator ofcubitus interruptus in hedgehog signalling. Nature, 386, 735-738 (1997).( IF=30.8)