医学部系列学术讲座之二十三

1、Dr. Paul Rothman

Talk title:

Mutations that Identify Novel Regulators of B Cell Development

Paul Rothman, MD, Professor, Dean of the Carver College of Medicine University of Iowa. He is also the Chair in Department of Internal Medicine.

He earned his medical degree at the Yale University School of Medicine in 1984. After completing his medical residency in 1986 at Columbia-Presbyterian Medical Center in New York City, he served on faculty at Columbia, becoming chief of the pulmonary, allergy, and critical care medicine division in 1997.

He is a member of the Council of the Association of American Physicians, American Society for Clinical Investigation, Association of Professors of Medicine, Collegium Internationale Allergologicum, and Association of American Physicians. He is a Fellow of the American College of Physicians. He has served as a member of the National Institutes of Health Immunologic Sciences Study Section; the Israel Cancer Research Fund International Scientific Advisory Board; the American Academy of Allergy, Asthma and Immunology Grant Review Committee; and the American Thoracic Society Asthma Immunology and Inflammation Program Committee.

Rothman's research on cytokines (immune system molecules) focuses on their role in the development of blood cells called leukocytes. Abnormal development of these blood cells can lead to leukemia. He also studies the role of cytokines in immune system responses to asthma and allergies.

2、Mariusz Z. Ratajczak, MD, PhD, DSci

Talk title:

Identification of very small embrynonic/epiblast like stem cells in adult tissues-physiological and pathological consequences

Hrney M. & Stella M. Hoenig Endowed Chair in Cancer Research; Professor of Medicine; Leader, Developmental Biology Program, James Graham Brown Cancer Center

Dr. Ratajczak obrained his MD from the Pomeranian Medical University in Szczecin, Poland, and his PhD from Polish Academy of Sciences in Warsaw, Poland. Since 1990 he is working as scientist in US. He spent 11 years at University of Pennsylvania in Philadelphia, where he was promoted to a rank of the Associate Professor. Four years ago Dr. Ratajczak joined the James Graham Brown Cancer Center as a Professor in the Department of Medicine and as Head of Stem Cell Biology Program at James Graham Brown Cancer Center.

Dr. Ratajczak's current research projects include

*The role of circulating stem cells in regeneration.

*The role of CXCR4-SDF-1 axis in cancer metastasis.

*The role of complement in stem cell homing/mobilization.

*Biological effects of microvesciles.

*Optimization of stem cell engraftment.

*Autocrine mechanism of hematopoiesis.

On a routine basis Dr. Ratajczak's laboratory isolates hematopoietic stem cells and TCSC from cord blood, mobilized peripheral blood and cadaveric bone marrow. He also has recently established a new strategy to isolate human epidermal stem cells as well as skeletal muscle stem cells. Both keratinocytes and muscle stem cells could be used for therapeutic purposes.

He is currently a section editor of Stem Cells, an associate editor of Folia Histochemica et Cytobiologica, a member of the editorial Board of Experimental Hematology, a Section Editor of Leukemia, Editor-in-Cheif, Central European Journal of Biology, and a member of Editorial Board, Journal of Cellular and Molecular Medicine.

Dr. Ratajczak is an elected Foreign Member of the Polish Academy of Arts

主持：张学光教授

时间：2008年11月12日下午14：00

地点：苏州大学独墅湖校区炳麟图书馆720会议室