题目：The urofacial syndrome (UFS), a unique model for dissecting the mechanism underlying voiding dysfunction
报告人：王从义博士
时间：2008年12月1日（周一）下午14：00
地点：独墅湖校区炳麟图书馆825会议室
报告人简介：
A. Position and Honors
Positions and Employment
07/07- Associate Professor, Center for Biotechnology & Genomic Medicine, Medical
07/07- Associate Professor,
07/02-06/07 Assistant Professor, Center for Biotechnology & Genomic Medicine,
05/03-06/07 Adjunct Assistant Professor, Department of Medicine, Medical College of Georgia, Georgia.
05/04-06/07 Assistant professor,
09/98-06/02 Research Assistant Professor in genetics and molecular biology, Department of Pathology,
09/92-7/95 Assistant Professor,
Honors: Treasurer: the Chinese Geneticists Society in
Executive Editorial Board: International Journal of Clinical and Experimental Pathology
Editorial Board member: Molecular Pain
Grant reviewer:
Grant review panel: NIH/NIDDK study section - Obesity/Nutrition Research Centers (ONRC) Special Emphasis Panel (2005).
Grant Reviewer, Ad hoc reviewer for MCG intramural grant programs (2006 - )
Innovation Award,
Manuscript reviews for Research Journals: Diabetes, Nucleic Acids Research, American Journal of Medical Genetics, Mutation, Human Genetics, Diabetes/Metabolism Reviews, Pediatric Diabetes, Journal of Autoimmunity, Medical Science Monitor, Molecular Medicine, International Journal of Cancer, Cellular Oncology, American Journal of Human Genetics, International clinical and experimental immunology, The Open pathology Journal, American Journal of transplantation, Transplantation and so on.
Professional Committees
- Member of the American Association for the Advanced of Science
- Member of the American Diabetes Association
- Member of the American Society of Human Genetics
- Member of the Immunology of Diabetes Society
- Member of the Chinese Geneticists Society in
Patents: 1). Activators of Cyclin-Dependent Kinases (ACDK). US and International Patent: PCT/US02/23147
2). A novel SUMO4 gene for type 1 diabetes susceptibility. US and International Patent: 7,173,119 B2
3). Ancient Conserved Domain Proteins (ACDP), a family of divalent ion transporters in mammalian cells. US and International Patent: 18-05
B. Publications since the appointment at the
1. Cong-Yi Wang, Abodoreza Davoodi-Semiromi, Jing-Da Shi, Ping Yang, Yi-Qun Huang, Jose A. G. Agundez, Jose M. Moran, Bernardo Ochoa, Bobbilynn Hawkins-Lee and Jin-Xiong She. (2003) High resolution mapping and mutation analyses of candidate genes in the urofacial syndrome (UFS) critical region. Am J Med Genet.
2. Cong-Yi Wang, Jing-Da Shi, Ping Yang, Pradeep G. Kumar, Quan-Zhen Li, Qing-Guo Run, Yun-Chao Su, Hamish S. Scott, Kuo-Jang Kao and Jin-Xiong She. (2003) Molecular Cloning and Characterization of a Novel Gene Family of Four Ancient Conserved Domain Proteins (ACDP). Gene 13;306:37-44.
3. Kenzo Tsuzuki, Ariel Ase, Pellipe Seguela, Cong-Yi Wang, Jin-Xiong She, Jianguo Gu. (2003) TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons. J Neurophysiol 89: (6):3235-42.
4. Cong-Yi Wang, Ping Yang, Jing-Da Shi, Sharad Purohit, Dehuang Guo Jian-Guo Gu, Jennifer Lin, Zheng Dong and Jin-Xiong She. (2004) Molecular Cloning and Characterization of the Mouse Acdp Gene Family. BMC Genomics 15;5(1):7. (Senior author)
5. Jinzhao Wang, Qingqing Wei, Cong-Yi Wang, William D. Hill, David C. Hess, Zheng Dong. (2004) Minocycline up-regulates Bcl-2 and protects against cell death in the mitochondria. J. Biol. Chem, 279(19):19948-54.
6. Dehuang Guo, Manyu Li, Yan Zhang, Ping Yang, Diane Hopkins, Weipeng Zheng, Sarah Eckenrode, Sharad Purohit, Andrew Muir, Paolo Pozzilli, Adina Zeidler, Leslie J. Raffel, Yongsoo Park, Manuel Serrano-Rios, Maria T. Martinez Larrad, Zixin Zhang, Henri-Jean Garchon, Jean-Francois Bach, Jerome I. Rotter Jin-Xiong She and Cong-Yi Wang. (2004) A functional variant of SUMO4, a novel IκBα modifier, is associated with type 1 diabetes. Nature Genetics 36(8):837-41. (Senior author)
7. Alba E Morales, Cong-Yi Wang, Jing-Da Shi, Jin-Xiong She and Andrew Muir. (2004) Novel TSHb subunit gene mutation causing congenital central hypothyroidism in a newborn male. Journal of Endocrinology & Metabolism 17(3):355-9.
8. Man Jiang, Xiaolan Yi, Stephen Hsu, Cong-Yi Wang and Zheng Dong. (2004) Role of P
9. Yiqiang Zhou, Hsin-Hsin Chang, Juan Du, Cong-Yi Wang, Zheng Dong and Mong-Heng Wang (2004) Renal epoxyeicosatrienoic acid synthesis during pregnancy. Am. J. physiol. 288(1):F221-6.
10. Manyu Li, Dehuang guo Carlos Isales, Mark Atkinson, Decio Eizirik, Jin-Xiong She and Cong-Yi Wang. (2005) SUMO wrestling with in type 1 diabetes (review). J. Mol. Med. 2005 Jul;83(7):504-13. (Senior author)
11.Wang CY, Yang P, She JX. Assessing the validity of the association between the SUMO
12. Craig Brooks, Pimonrat Ketsawatsomkron, Yang Sui, Jinzhao Wang, Cong-Yi Wang, Fu-Shin Yu, Zheng Dong (2005) Acidic pH Inhibits ATP depletion-induced Tubular Cell Apoptosis by Blocking Caspase-9 Activation in Apoptosome. Am. J. physiol. 2005 Mar 8; [Epub ahead of print].
13.Hui Huang, Yiqiang Zhou, Venugopal T. Raju, Juan Du, Hsin-Hsin Chang, Cong-Yi Wang, Michael W. Brands, John R. Flack and Mong-heng Wang (2005) Renal 20-hydroxyeicosatetraenoic acid inhibition attenuates the changes of renal hemodynamics induced by N-nitro-L-arginine methyl ester treatment in pregnant rats. Am. J. physiol. 2005 Jul 5; [Epub ahead of print]
14.Dehuang Guo, Jin-Xiong She, Mong-Heng Wang, Jennifer Ling, Jianguo Gu and Cong-Yi Wang. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP
15.Dehuang Guo, Junyan Han, Nancy H Colburn, Mong-Heng Wang, Zheng Dong, Decio L Eizirik, Jin-Xiong She, and Cong-Yi Wang (2005). Proteomic analysis of SUMO4 Substrates in HEK293 Cells under Serum Starvation-induced Stress. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1308-18. Epub 2005 Oct 10. (Senior author)
16.Yanping Tang, Ying Wang, Yuan Liu, Bo Wang, Robert Podolsky, Richard McIndoe and Cong-Yi Wang (2006) Intergeneration CAG expansion and contraction in a Chinese HD family Am J. Med. Genet. 2006 Apr 5;141B(3):242-4. (Senior author)
17.Yiqiang Zhou, Hui Huang, Hsin-Hsin Chang, Juan Du, Cong-Yi Wang and Mong-Heng Wang (2006) Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat-diet induced hypertension in rats. Journal of Parmacology and Experimental Therapeutics. 2006 Apr;317(1):11-8. Epub 2005 Dec 8
18.Cong-Yi Wang, Robert Podolsky and Jin-Xiong She (2006) Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene. Ann. N. Y. Acad. Sci. 1079:257-267. (Senior author)
19.Jinzhao Wang, Navjotsingh Pabla, Cong-Yi Wang, Weixin Wang, Patricia V. Schoenlein and Zheng Dong (2006) Caspase-mediated of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity towards p53. Am. J. physiol. EPub August, 2006
20.Jiang M, Wei Q, Pabla N, Dong G, Wang CY, Dong Z. Role of hydroxyl radicals in p53 activation during cisplatin-induced tubular cell apoptosis and nephrotoxicity. Journal of American Society of Nephrology 2006 Dec;291(6):F1300-7. Epub 2006 Jul 18.
21.Yafei Huang, Hui Yin, Junyan Han, Baojun Huang, Junfa Xu, Fang Zheng, Zheng Tan, Min Fang, Cong-Yi Wang and Feili Gong (2007) Extracellular Hmgb1 functions as an innate immune-mediator implicated in murine cardiac allograft acute rejection. American Journal of Transplantation. 2007 Apr;7(4):799-808. Epub 2007 Feb 28. (Co-senior author)
22.Jun-Fa Xu, Bao-Jun Huang, Hui Yin, Ping Xiong, Wei Feng, Yong Xu, Min Fang, Fang Zheng, Cong-Yi Wang, and Fei-Li Gong (2007) A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allografts Transplant International 20(3):266-76.
23.Man Jiang , Qingqing Wei, Navjotsin Pabla, Guie Dong, Cong-Yi Wang, Tianxin Yang, Sylvia B. Smith, Zheng Dong (2007) Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity Biochemical Pharmacology 73 (2007) 1499– 1510.
24.Cong-Yi Wang and Jin-Xiong She (2007) SUMO4 and its role in type 1 diabetes pathogenesis. Diabetes/Metabolism Research and Reviews 2008 Feb;24(2):93-102. (Senior author)
25.Guang Yu, Min Fang, Min Gong, Li Liu, Jixin Zhong, Wei Feng, Ping Xiong, Cong-Yi Wang and Feili Gong. Steady state dendritic cells with ectopic IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Transplantation Immunology 2008;18(3):208-19.
26.Huifang Liang, Bingjiao Yin, Lixia Huang, Jianhua Zhu, Qingling Zeng, Shu Zhang, Jin Wang, Xiaodan Jiang, Feng Wei, Qingfen Li, Cong-Yi Wang and Zhuoya Li (2007) Blockade of TNFR1-mediated TNF-α signaling protected Wistar rats from HFS-induced obesity and insulin resistance. Endocrinology 2008 Mar 13; [Epub ahead of print]
27.Junyan Han, Wenzhong Wei, Ping Yang, Ying Wang, Zheng Dong, Mong-Heng Wang, jin-Xiong She, David Stern and Cong-Yi Wang (2007) Blockade of extracellular Hmgb1 prevents the development of autoimmune diabetes in NOD mice. Diabetes. 2008 May 13. [Epub ahead of print] (Senior author)
28.Junyan Han, Ping Yang, Wenzhong Wei, Sharad Purohit, Robert Podolsky, Jin-Xiong She and Cong-Yi Wang (2007) ALR genome unique to NOD mice encodes determinants for dendritic cells function. Autoimmunity (Senior author, in press)
29.Zhou, Z, Han, J, Xi, C, Xie, J, Feng, X, Wang, CY, Mei, L, Xiong, WC. HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE. J Bone Miner Res. 2008 Feb 26 [Epub ahead of print]
30.Wenzhong Wei, Ying Wang, Ping Yang, Mong-Heng Wang, Zheng Dong, Jin-Xiong She and Cong-Yi Wang (2008) SUMO4 undergoes a progressive degradation in cells under physiological condition but mediates sumoylation in stressed cells. BBRC (Senior author, in press)
31.Dong, G, Wang, L, Kumar V, Wang, CY and Dong, Z. Induction of Apoptosis in Renal Tubular Cells by Histone Deacetylase Inhibitors, a Family of Anticancer Agents. J Pharmacol Exp Ther. 2008 Feb 29 [Epub ahead of print]
32.Yiqiang Zhou, Pengcheng Luo, Hsin-Hsin Chang, Hui Huang, Tianxin Yang, Zheng Dong, Cong-Yi Wang, and Mong-Heng Wang. (2008) Activation of PPAR_ by clofibrate attenuates hypertension and sodium retention in DOCA-salt-treated mice. Kidney International 2008 Jul 2. [Epub ahead of print]
33.Yushan Zhang, Wenzhong Wei, Guichuan Han, Jixin Zhong, Richard White, Zheng Dong, Yunchao Su and Cong-Yi Wang. Sumoylation in the regulation of endothelial angiogenesis. Am. J. physiol. (Senior author, in press)
34.Ping, Yang, Manyu Li, Dehuang Guo, Feili Gong, Bao-Ling Adam, Mark A. Atkinson and Cong-Yi Wang. Comparative analysis of the islet proteome between NOD/Lt and ALR/Lt mice. Ann. N. Y. Acad. Sci. (Senior author, in press)
35.Zhimin Miao, Changgui Li, Ying Chen, Shihua Zhao, Yangang Wang, Zhongchao Wang, Xinyan Chen, Feng Xu, Fang Wang, Ruixia Sun, Jianxia Hu, Wei Song, Shengli Yan and Cong-Yi Wang. (2008) Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the
36.Peng Gao, Yan Jiao, Qing Xiong, Cong-Yi Wang, Ivan Gerling, Weikuan Gu. (2008) Genetic and molecular basis of QTL of diabetes in mouse: genes and polymorphisms. Current Genomics (in press)
37.Hong Xing, Jennifer X Ling, Meng Chen, Richard D Johnson, Makoto Tominaga, Cong-Yi Wang and Jianguo Gu. (2008) TRPM8 mechanism of autonomic nerve response to cold in respiratory airway. Mol Pain. 2008 Jun 5;4:22.
(科研办公室)
