讲座一
题 目：Cancer,with a discussion of the role mutations and genomic instability in the development of cancer
报告人：Dr.Alison Adams
Department of Biological Sciences Northern Arizona University
时 间：2008.12.16（周二）下午2：00
地 点：独墅湖校区炳麟图书馆720会议室
讲座二
题 目：Use Yeast to understand genomic instability and cancer
报告人：Dr.Alison Adams
Department of Biological Sciences Northern Arizona University
时 间：2008.12.17（周三）下午2：00
地 点：独墅湖校区炳麟图书馆720会议室
讲座三
题 目：Yeast Saccharomyces cerevisiae,and it is strengths as a model organism
报告人：Dr.Alison Adams
Department of Biological Sciences Northern Arizona University
时 间：2008.12.18（周四）下午2：00
地 点：独墅湖校区炳麟图书馆720会议室
报告人简介：
EDUCATION
B.A.: University of Dublin, Trinity College, Dublin, Ireland 1978
Major: Genetics
(Graduated with Honors)
Ph.D.: University of Michigan, Ann Arbor, MI 1984
Major: Biology
Laboratory of Dr. John Pringle
Dissertation: "Cellular Morphogenesis in the Yeast
Saccharomyces cerevisiae"
Postdoctoral: University of Edinburgh, Edinburgh, Scotland 1985
Laboratory of Dr. Jean Beggs
Massachusetts Institute of Technology, Cambridge, MA 1986-88
Laboratory of Dr. David Botstein
Genentech, Incorporated, South San Francisco, CA 1988-90
Laboratory of Dr. David Botstein
Major Fields: Genetics, Cell Biology, Cancer Biology
RESEARCH INTERESTS
Use of genetics in the yeast Saccharomyces cerevisiae to study cellular processes including (i) cellular morphogenesis, and (ii) genomic instability, using genetic, molecular-genetic, cell biological, and biochemical methods.
PRESENT POSITION
July 2006- Associate Professor
Department of Biology
Northern Arizona University, Flagstaff, AZ
April 2005- Full Investigator,
Arizona Cancer Center, Tucson, AZ.
HONORS AND AWARDS
1977 Irish-American Foundation Award, University of Dublin
1980-84 Literature, Science and Arts Award, University of Michigan
1982-83 Horace H. Rackham School of Graduate Studies Predoctoral FELLOWSHIP
1982-84 Edwin H. Edwards Award, University of Michigan
1983-84 Cancer Research Institute Predoctoral Fellowship, University of Michigan
1985 Medical Research Council Research Grant
1990 Biomedical Research Support Grant, University of Arizona ($10,300)
Small Grants Program, University of Arizona ($5,000)
Institutional Cancer Research Grant ($6,600)
1992 American Society for Cell Biology, Women in Cell Biology Junior Award
1996 Nominee for Professor of the Month, University of Arizona ASUA.
2005 NAU Intramural Grants Program Award ($6,400)
2006 NAU Intramural Grants Program Award ($9,520)
MSD Faculty Mentor Award ($5,000)
REFEREED JOURNALS
Sloat, B.F., A. Adams, and J.R. Pringle. 1981. Roles of the CDC24 gene product in cellular morphogenesis during the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 89: 395-405.
**Adams, A.E.M., and J.R. Pringle. 1984. Relationship of actin and tubulin distribution to bud growth in wild-type and morphogenetic-mutant Saccharomyces cerevisiae. J. Cell Biol. 98: 934-945.
**Kilmartin, J.V., and A.E.M. Adams. 1984. Structural rearrange­ments of tubulin and actin during the cell cycle of the yeast Saccharomyces. J. Cell Biol. 98: 922-933.
*Jacobs, C.W., A.E.M. Adams, P.J. Szaniszlo, and J.R. Pringle. 1988. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 107: 1409-1426.
***Adams, A.E.M., and D. Botstein. 1989. Dominant suppressors of yeast actin mutations that are reciprocally suppressed. Genetics 121: 675-683.
***Adams, A.E.M., D. Botstein, and D.G. Drubin. 1989. A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation. Science 243: 231-233.
Adams, A.E.M., D.I. Johnson, R.M. Longnecker, B.F. Sloat, and J.R. Pringle. 1990. Two new genes involved in budding and the estab­lishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell Biol. 111: 131-142.
Haarer, B.K., S.H. Lillie, A.E.M. Adams, Magdolen, W. Bandlow, and S.S. Brown. 1990. Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells. J. Cell Biol. 110: 105-114.
*Adams, A.E.M., D. Botstein, and D.G. Drubin. 1991. Yeast fimbrin is required in vivo for actin organization and morphogenesis. Nature 354: 404-408.
Adams, A.E.M., J.A. Cooper, and D.G. Drubin. 1993. Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast. Mol. Biol. Cell. 4:459-468.
****Honts, J.E., T.S. Sandrock, S.M. Brower, J.L. O'Dell, and A.E.M. Adams. 1994. Actin mutations that show suppression with fimbrin mutations identify a likely fimbrin-binding site on actin. J. Cell Biol. 126:413-422.
*Adams, A.E.M., W. Shen, C.-S. Lin, J. Leavitt, and P. Matsudaira. 1995. Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin. Mol. Cell. Biol. 15:69-75.
*Brower, S.M., J.E. Honts, and A.E.M. Adams. 1995. Genetic analysis of the fimbrin-actin binding interaction in Saccharomyces cerevisiae. Genetics 140:91-101.
Mathias, N., S.L. Johnson, M. Winey, A.E.M. Adams, L. Goetsch, J.R. Pringle, B.E. Byers, and M.G. Goebl. 1996. Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1 to S phase transition and identifies a conserved family of proteins. Mol. Cell. Biol. 16:6634-43
DeMarini, D.J., A.E.M. Adams, H. Fares, C. De Virgilio, G. Valle, J.S. Chuang, and J.R. Pringle. 1997. A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. J. Cell Biol. 139:75-93.
***Sandrock, T.M., J.L. O'Dell, and A.E.M. Adams. 1997. Allele-specific suppression by formation of new protein-protein interactions. Genetics. 147:1635-42.
Suppressor analysis of fimbrin (Sac6p) overexpression in yeast. Genetics 151: 1287-97.
*Whitacre, J.L., D. A. Davis, K.A. Toenjes, S.M. Brower, and A.E.M. Adams. 2001. Generation of an isogenic collection of yeast actin mutants and identification of three interrelated phenotypes. Genetics. 157(2):533-43.
Munshi, R., K.A. Kandl, A. Carr-Schmid, J.L. Whitacre, A.E.M. Adams and T. G. Kinzy. 2001. Over-expression of translation elongation factor 1A affects the organization and function of the actin cytoskeleton in yeast. 2001. Genetics. 157 (4): 1425-36.
*Kandl, K.A., R. Munshi, Ortiz P.A., Andersen, G.R., Kinzy, T.G., and A.E.M. Adams 2002. Identification of a role for actin in translational fidelity in yeast. Molecular Genet. Genomics. 268 (1) 10-18
CURRENT PROFESSIONAL MEMBERSHIP:
2006- American Society of Microbiology
2007- American Society for Cell Biology
(学部办公室)
