学术讲座: Regulation of PTEN by Rho Small GTPases

发布者：系统管理员发布时间：2008-12-25浏览次数：1091


报告人: 李忠博士

地点: 苏州大学独墅湖校区医学楼403- 3119室

时间: 12月26日下午2:00

Experience:

1984-1985 Residence, the First Hospital of Henan, Zhengzhou, China

1985-1987 Assistant Researcher, Laboratory of Esophageal Cancer Research, Henan Medical University, Zhengzhou, China

1997-1990 MS student in Pathophysiology, Henan Medical University, China

1991-1993 Lecturer, Laboratory of Esophageal Cancer Research, Henan Medical University, Zhengzhou, China

1993-1996 PhD student in Biochemistry, Shanghai Medical University, Shanghai, China

1996-1997 Postdoctoral fellow, Shanghai Institution of Biochemistry, Shanghai, China

1997-1999 Postdoctoral fellow, Department of Pharmacology and Physiology, University of Rochester, NY

2000-2003 Postdoctoral fellow, Department of Genetics and Developmental Biology, Farmington, CT

2004- Assistant Professor, Department of Genetics and Developmental Biology, Farmington, CT

2007- Assistant Professor, Department of Neurology, Farmington, CT

Publication Listing:

  1. Zhenglong Wang, Xuemei Dong, Zhong Li, Jonathan D. Smith, Dianqing Wu. Lack of a significant role of P-Rex 1 a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis. Prostaglandins and Other Lipid Mediators. 2008 online preview.
  2. Zhenglong Wang, Sun-Il Hwang, Bei Lu, Zhong Li, Xuemei Dong, Ping Wang1, Carlos, Fernandez-Hernando, Wenwen Xu, Timothy Hla, Jonathan D. Smith, Zihai Li, David Han,Kevin Claffey, Dianqing Wu. Phospholipaseβ3-deficiency attenuates atherogenesis by sensitizing macrophages to apoptotic induction by oxysterols. In press. J Clin Invest. 118(1):195-204, 2008
  3. Zhenglong Wang, Sun-Il Hwang, Bei Lu, Zhong Li, Xuemei Dong, Ping Wang1, Carlos, Fernandez-Hernando, Wenwen Xu, Timothy Hla, Jonathan D. Smith, Zihai Li, David Han,Kevin Claffey, Dianqing Wu. Phospholipase C β3-deficiency leads to macrophage hypersensitivity to apoptotic induction and atherogenesis reduction. In press. Journal of Clinical Investigation. 2007
  4. Xuemei Dong, Zhicheng Mo, Gary Bokoch, Caiying Guo, Zhong Li*, and Dianqing Wu*. (2005a) P-Rex1 is a primary Rac2 Guanine Nucleotide Exchange Factor in mouse neutrophils. Current Biology, 15:1874-1879.
  5. *Zhong Li, Jie-Hye Paik, Zhenglong Wang, thim Hla, and Dianqing Wu. Role of guanine nucleotide exchange factor P-Rex2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins & Other Lipid Mediators, 76(1-4):95-104, 2005
  6. Zhonh Li, Xuemei Dong, Zhenglong, Wang, Wenzhong Liu, Ning Deng, Yu Ding, Liuya Tang,Tim Hla, Rong Zeng, Lin Li and Dianqing Wu. Regulation of PTEN by Rho Small GTPases. Nature Cell Biology, 7(4):399-404, 2005
  7. Zhong Li, Michael Hannigan, Zhicheng Mom Bo Liu, Wei Lu, Yu Wu, Alan V. Smrcka, Guangqing Wu, Mingyao Liu, Chikuang Huang, and Diangqing Wu. Direction sensing requires Gβγ-mediated by Pak1 and PIXα-dependent Activation of Cdc42. Cell. 114, 215–227, 2003.
  8. Michael Hannigan, Lijun Zhan, Zhong Li, Youxi Ai, Dianqing Wu, Chi-Kuang Huang. Neutrophils lacking phosphoinositide 3-kinase g show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. PNAS, 99:3603-3608, 2002.
  9. Xiaoqing Gan, Jiyong Wang, Qiheng Yang, Zhong Li, Feng Liu, Gang Pei, and Lin Li. Interaction between the conserved region in the C-terminal domain of GRK2 and Rhodopsin is necessary for GRK2 to catalyze receptor phosphorylation. J. Biol. Chem. 275(12) :8469-8474, 2000.
  10. Zhong Li, Huiping Jiang, Wei Xie, Zuchuan Zhang, Alan V. Smrcka, and Dianqing Wu. Role of PLC-β2 and -β3 and PI3Kγin Chemoattractant-mediated signal transduction. Science. 287(5455):1046-1049, 2000.
  11. Zhong Li, Aihua Liu, Fei Liu, Huili Chen. Modification of pentasaccharide core of surface N-glycans during differentiation of HL-60 cells. Leukemia Res. 22(8):727-734, 1998.
  12. Aihuan Liu, Fei Liu, Zhong Li, Jianxing Gu, Huili Chen.Alterations on glycosyltransferases during myeloid and monocytoid differentiation of HL-60 cells. Cell Biology International. 22(7-8):545-550, 1998.
  13. Zhong Li, Huili Chen. Changes of protein kinase C isoforms during induced differentiation of HL-60 cells. ACTA Biologiae Experimentalis SINICA. 30(2): 201-207, 1997.
  14. Zhong Li, Guiting Liu, Yuzhen Qian. Effect of AME on intracellular cyclic nucleotides levels in human lymphocytes. Chinese J. Pathophysiology. 10(4): 374-377, 1994.
  15. Xiulin Wang, Zhong Li, Yingzhong Zhen, Aiyun Song, Shaoyin Han. Four kinds of smoke condensation increase the unscheduled DNA synthesis of rat lung cells. ACTA Henan Med.Uni . 26(4): 314-317,1991.
  16. Zhong Li, Guiting Liu. Effect of Alternariol monomethyl ether on cellular immune. ACTA Henan Med.Uni. 26(4): 393, 1991.
  17. Zhong Li, Guiting Liu, Yuzhen Qian, Yaou Gong, Zhimin Zheng, Xiulin Wang, Yangzhong Zhen. Effect of Alternariol monomethyl ether on proliferation response of human lymphocytes. Research on Prevention and Treatment of Cancer. 18(3): 154-156, 1991.

* Corresponding author

Research Support:

Active support:

AHA 0530171N Jan 1, 2005-Dec 31, 2008

Scientist Development Grant, American Heart Association

Role: PI

Role of Chemoattractants in Atherosclerosis

NIH 5PO1-HL070694 Dec 1, 2003-June 30, 2006

Macrophage/monocyte signaling in vascular pathophysiology

Role: Co-investigator

NIH 5RO1-HL080706-11 April, 1, 2006-June 31, 2007

Molecular function of chemoattractant-mediated signaling

Role: Co-investigator

(基础医学与生物科学学院)