时间：2009年3月6日下午3:00
地点：独墅湖校区701号楼601室
报告人：段宏伟博士
摘要：
纳米技术的发展为人类重大疾病的检测和治疗提供了新型的技术平台。本报告将介绍我们在设计基于生物相容高分子以及无机半导体荧光量子点的生物成像和药物（抗癌药物和siRNA）释放体系的最新进展。
The development of ultra-sensitive diagnostic techniques and highly efficient and specific therapeutic platforms for major human diseases, especially various types of cancer has become the central focus of nanotechnology. Nanoparticles have been specifically directed to tumor through both passive and active targeting approaches by taking advantaging of the tumor-featured enhanced permeability and retention (EPR) effect or molecular recognition of targeting ligands. This talk introduces our recent work on developing multi-functional nanoparticles, built upon self-assembled polymeric nanoparticles and fluorescent semiconductor quantum dots, for integrated cancer imaging (optical imaging and magnetic resonance imaging) and therapy (anticancer drugs and siRNA).
简介：段宏伟博士，1976年12月生，1995到1999就读复旦大学化学系；1999至2002 就读复旦大学高分子系（导师：江明院士）；2005在Max Planck Institute of Colloids and Interfaces获得博士学位（导师：Prof. Helmuth Moehwald）；2005 起在艾默雷大学及佐治亚理工大学（Emory University & Georgia Institute of Technilogy）生物医学工程系从事博士后研究（导师：聂书明教授）；2008-9月起在该系任研究助理教授。目前的主要研究兴趣包括：新型生物纳米材料的合成，生物成像，癌症靶向药物及其多功能复合体系。
代表论文：
1. Yi Shen, Min Kuang, Zhong Shen, Jörg Nieberle, Hongwei Duan*, Holger Frey, “Thermosensitive Hyperbranched Polyelectrolyte-Coated Gold Nanoparticles: Towards Smart Temperature- and pH-Nanosensors”, Angew. Chem. Int. Ed. 2008, 47, 2227. (通讯作者)
2. Hongwei Duan, Shuming Nie, “Cell Penetrating Quantum Dots Based on Multivalent and Endosome-Disrupting Surface Coatings”, J. Am. Chem. Soc. 2007, 129, 3333.
3. Hongwei Duan, Shuming Nie, “Etching Colloidal Gold Nanocrystals with Hyperbranched and Multivalent Polymers: A new Route to Fluorescent and Water-Soluble Atomic Clusters”, J. Am. Chem. Soc. 2007 129, 2412.
4. Zhong Shen, Hongwei Duan*, Holger Frey, “Water-Soluble Fluorescent Ag-Nanoclusters Obtained from Multi-Arm Star Poly(Acrylic Acid) as “Molecular Hydrogel” Template”, Adv. Mater. 2007, 19, 349. (通讯作者)
5. Hongwei Duan, Dayang Wang, Dirk G. Kurth, Helmuth Möhwald, “Magnetic Colloidosomes with Defined Permeability Derived from Self-Assembly of Nanoparticles at Oil/Water Interfaces”, Nano Lett. 2005, 5, 949.
6. Hongwei Duan, Min Kuang, Dayang Wang, Dirk G. Kurth, Helmuth Möhwald, “Colloidally Stable and Amphibious Nanocrystals Derived from Poly[(2-dimethyl amino)ethyl methacrylate] Capping”, Angew. Chem. Int. Ed. 2005, 43, 1717.
7. Hongwei Duan, Dayang Wang, Dirk G. Kurth, Helmuth Möhwald, “Directing Self-assembly of Nanoparticles at Water/Oil Interfaces”, Angew. Chem. Int. Ed. 2004, 42, 5639.
8. Hongwei Duan, Daoyong Chen, Ming Jiang, Wenjun Gan, Shanjun Li, Min Wang, Jie Gong, “Self-Assembly of Unlike Homopolymers into Hollow Spheres in Non- selective Solvent”, J. Am. Chem. Soc. 2001, 123, 12097.
发明专利：
Hongwei Duan, Min Kuang, Shuming Nie, “Branched Multifunctional Nanoparticle Conjugates and Their Use”, filed in 2008, 美国专利，国际专利
(科研办公室)
