唐仲英血液研究中心学术讲座

发布者：吴德建发布时间：2009-03-30浏览次数：1130


讲座一：

题目：

A New Concept of Tumor Development: The Road Map toward Cure of Cancer

肿瘤发展新概念:走向根治肿瘤的新途径

报告人：Jian-Xin Gao, M.D., Ph.D.

讲座二：

题目：

Role and Mechanism of MicroRNA-22 in Acute B Lymphocyte Leukemia.

报告人：黄士昂教授、主任医师、博士生导师

时间：2009年4月2日下午2：00

地点：苏州大学独墅湖新校区703号楼3331会议室

个人简介：

1、Jian-Xin Gao, M.D., Ph.D.

1989/03 – 1991/03 Assistant Professor, Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai, China

1991/4 – 19995/04 Associate Professor, Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai, China

1994/12 - 1996/12 Research Associate, Transplantation Immunobiology Group, The John P. Robarts Research Institute, Western Ontario University, London ,Ontario, Canada

1997/01 - 1999/4 Research Associate, Autoimmunity/Diabtes Group, The John P. Robarts Research Institute, Western Ontario University, London, Ontario, Canada; Hemosol Inc., Etobicoke, Ontario, Canada.

1999/05 – 2004/04 Research Scientist and Clinical Assistant Professor, Department of Pahtology, The Ohio State University, Columbus, Ohio, USA.

2000 - 2003 Faculty member (M status) Graduate School, Ohio State University

2003 – present Faculty member (P status), Graduate School, OhioStateUniversity

2003/01 to 2004/04 Assistant professor (mentored), Department of Pathology, The Ohio State University, Columbus, Ohio, USA.

2003/07 to present Member, Comprehensive Cancer Center Immunology Program, The Ohio State University.

2003/04 to present Faculty member, Integrated Biomedical Science Graduate Program (IBGP), College of Medcine and Public Health, The Ohio State University, Ohio, USA

2003 to present Member, Comprehesive Cancer Center, Ohio State University

2004/05 to present Assistant Professor, Department of Pathology, The Ohio State University.

2004/07 to 2007/6 Visiting professor, Institute of Zoology, ChineseAcademy of Science

近二年发表的论文：

1、Yu-Xia Yang, Zhen-Chuan Miao, Hao-Jian Zhang, Yun Wang, Jian-Xin Gao, Mei-Fu Feng (2007) Establishment and characterization of a human telomerase catalytic subunit-transduced fetal bone marrow-derived osteoblastic cell line. Differentiation, 75:24-34.

2、Li Chen, Rulong Shen, Yin Ye, Xin-An Pu, Xingluo Liu, Wen-Rui Duan, Jin Wen, Jason Zimmerer, Ying Wang, Yan Liu, Larry C. Lasky, Nyla Heerema, Danilo Perrotti, Keiko Ozato, Satomi Kuramochi-Miyagawa, Toru Nakano, Allen J. Yates, William E. Carson III, Haifan Lin, Sanford H. Barsky, Jian-Xin Gao (2007) Precancerous Stem Cells Have the Potential for Both Benign and Malignant Differentiation. PLoS One 2:e293.

3、Li Chen, Edward Calomeni Jing Wen, Rulong Shen, and Jian-Xin Gao (2007) Natural killer dendritic cells are an intermediate of developing dendritic cells. J Leukocyte Biol, 81:1422-33.

4、Rulong Shen, Yin Ye, Li Chen, Qingtoa Yan, Sanford H. Barsky, Jian-Xin Gao (2008) Precancerous stem cells can serve as tumor vasculogenic progenitors, PLoS One, PLoS ONE 3:e1652.

5、Jian-Xin Gao (2008) Cancer stem cells: the lesson from precancerous stem cells, J Cell Mol Med, 12: 67-96.

6、Yin Ye, Yi Xiao, Wenting Wang, Kurtis Yearsley, Jian-Xin Gao, Sanford H. Barsky (2008) ERαsuppresses slug expression directly by transcriptional repression, Biochem J. 416(2):179-87.

7、Rulong Shen, Lianhui Tao, Yiqing Xu, Shi Chang, James Van Brocklyn and Jian-Xin Gao (2009) Reversibility of aberrant global DNA and estrogen receptor-α gene methylation distinguishes the colorectal precancer from cancer. Int J Clin Exp Pathol. 2:21-33.

8、Xiaogang Pan, Li Chen, Shujun Liu, Jian-Xin Gao (co-corresponding author), Robert J. Lee (2009) Antitumor Activity of G3139 Lipid Nanoparticles (LNPs), Molecular Pharmaceutics, 6:211–220.

9、Charles Cook, Jin Wen, Yang Liu, Jian-Xin Gao (2009) CD28/B7 costimulation critical for early control of murine cytomegalovirus infection. Viral Immunol, in press.

10、Gao, J. X., and Q. Zhou. 2009. Epigenetic Progenitors in Tumor Initiation and Development. Drug Discovery Today: Disease Models: http://dx.doi.org/10.1016/j.ddmod.2009.01.001

11、Li Chen, Qingtao Yan, Yin Ye, Detao Yin, Rulong Shen, Sanford Barsky and Jian-Xin Gao (2009) CD25+Foxp3+ regulatory T cells suppress the expansion of autoreactive T cells in vivo, but not their activation, division and effector functions. Submitting.

12、Yin Ye, De-Tao Yin, Li Chen, Quansheng Zhou, Qingtao Yan, Rulong Shen, Qien Wang, Altaf Wani, Gang He, Toru Nakano, Haifan Lin, Sanford Barsky, Jian-Xin Gao (2009) PL2L1, a piwil2­like protein, is predominantly expressed in tumor cells and promotes their growth, Submitting.

13、Yin Ye, Qingtao Yan, Yi Xiao, Rulong Shen, Sanford Barsky, Jian-Xin Gao (2009) Cancer embryonic and germline stem cell (CEG) gene PIWIL2 is a barrier for tumor initiation and progression, submitting.

14、Li Chen, Qingtao Yan, James Waldman, Yin Ye, Sandford H. Barsky, Rulong Shen, Jian-Xin Gao (2009) Immunoprevention of cancer through targeting of precancerous stem cells, submitting.

15、Rulong Shen, Sanford Barsky, Jian-Xin Gao (2009) Piwil2 is an early biomarker for cancer development, in preparation.

16、Rulong Shen, James Liu, Sanford Barsky, Jian-Xin Gao (2009) Piwil2 can serve as a biomarker for detection of breast precancer, in preparation.

2、黄士昂

华中科技大学同济医学院附属协和医院及湖北省干细胞研究与应用中心主任，血液病研究所副所长，湖北省生物靶向治疗重点实验室主任。1983年获同济医科大学学士学位（医疗系），1986年获同济医科大学内科血液专业硕士学位，导师王辩明教授、李崇渔教授，1986-1989年在同济医科大学附属协和医院内科、血液病研究所任住院医师和主治医师。1989年至2001在美国从事医学研究十多年，先后在Becton Dickinson，Apply Imaging，加州大学圣迭哥分校肿瘤中心等做博士后、研究科学家、高级科学家、副研究员和首席技术执行官。在国际专业杂志发表论文20余篇，SCI引用近1900次，是人造血干细胞主要生物标志（CD34+CD38-）及其分离纯化方法的主要作者和发明人之一，获相关美国及欧洲专利，1998年获美国血液和骨髓移植协会最佳青年论文奖（摘要），1998年国际血液治疗和移植工程协会最佳年度论文奖（摘要），2000年获国家自然基金海外杰出青年基金白血病干细胞课题一项，2002年获科技部重大基础研究项目（973）子项目一项，2003年获国家自然基金杰出青年基金一项。2002年组建湖北省干细胞研究与应用中心，2005年组建湖北省生物靶向治疗重点实验室，2005年经省卫生厅批准，首次在湖北省开展自体免疫细胞治疗临床应用新技术。是美国血液学会和美国科学促进会会员。

自回国工作以来，黄士昂教授带领团队已在白血病研究中分别积累了上千例的免疫表型、细胞遗传和分子生物学研究资料，相关研究结果已在《白血病（Leukemia）》等国际杂志上发表了8篇SCI收录论文，IF6.0以上2篇，其中6篇为通讯作者。成功建立了多色高分辨流式细胞技术、多色流式细胞分选、体外单细胞克隆培养、细胞周期与细胞凋亡检测、染色体核型与FISH检测、定量PCR与基因突变检测技术等平台，相关实验方法和其检测分析出的结果，均已在国际专业杂志上发表。

主要学术论文（*为通讯作者）：

  1. Terstappen L. WMM, Huang S, Safford M, Lansdorp PM, Loken MR: Sequential generations of hematopoietic colonies derived from single lineage committed CD34+CD38- progenitor cells. Blood 77: 1218, 1991

  2. Terstappen L. WMM, Huang S, Picker JL: Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow. Blood 79: 667, 1992

  3. Huang S, Terstappen L. WMM: Formation of hematopoietic microenvironment and hematopoietic stem cells from single human bone marrow stem cells. Nature 360: 745, 1992

  4. Huang S, Terstappen L. WMM: Myeloid and lymphoid differentiation of single human hematopoietic stem cells. Blood 83: 1515, 1994

  5. Terstappen L. WMM, Huang S: Analysis of bone marrow stem cells. Blood Cells 20: 45, 1994

  6. Huang S, Terstappen L. WMM: Correction: Formation of hematopoietic microenvironment and hematopoietic stem cells from single human bone marrow stem cells. Nature 368: 664, 1994

  7. Moore T, Huang S, Terstappen L. WMM, Bennett M, Kumar V: Expression of CD43 on murine and human pluripotent hematopoietic stem cells. J Immunol 153: 4978, 1994

  8. Waller EK, Huang S, Terstappen L. WMM: Changes in the growth properties of CD34+, CD38- bone marrow progenitors during human fetal development. Blood 86: 710, 1995

  9. Huang S, law P, Young D, Ho AD: Candidate hematopoietic stem cells from fetal tissues, umbilical cord blood vs. adult bone marrow and mobilized peripheral blood. Experimental Hematology26: 1162, 1998

  10. Huang S, Law P, Francis K, Palsson BO, Ho AD: Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules.Blood, 94:2595, 1999

  11. Huang S, Chen Z, Young D, Ho AD, Huang ECM, Law P: Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues. Stem Cell, 17:265, 1999

  12. Tian H, Huang S, Gong F, Tian L, Chen Z: Karyotyping, immunophenotyping, and apoptosis analyses on human hematopoietic precursor cells derived from umbilical cord blood following long-term ex vivo expansion. Cancer Genetics and Cytogenetics, 17: 33-36 2005

  13. Wang X, Zheng J, Liu J, Yao J, He J, Li X, Yu J, Yang J, Huang S*. Increased population of CD4+CD25high regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients. Eur J Haematol, 75: 468, 2005

  14. Chen Z, Issa B,Huang S, Aston E, Brothman AR, Glenn M. A Practical Approach to the Detection of Prognostically Significant Genomic Aberrations in Multiple Myeloma. JMD (Journal of Molecular Diagnostics) 7: 560-665 2005

  15. J Yang, J Liu, J Zheng, W Du, Y He, W Liu and S Huang*.A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia. Leukemia, 2007, Sep;21(9):2072-4

  16. Xiaoqing Li, Jing Yang, Xiangjun Chen, Jun Liu, Hongrui Li, Jine Zheng, Yanli He, Zhong Chen, Shiang Huang*.A report of early cytogenetic response to imatinib in two patients with CML at accelerated phase and carrying the e19a2 BCR-ABL transcript. Cancer Genetics and Cytogenetics, 2007,176: 166-168.

  17. Jine Zheng, Xingbing Wang, Yu Hu, Jing Yang, Jun Liu, Yanli He, Qing Gong, Junxia Yao, Xiaoqing Li, Wen Du, and Shiang Huang*. A Correlation Study of Immunophenotypic, Cytogenetic, and Clinical Features of 180 AML Patients in China. Clinical Cytometry, 2008,74B: 25-29.

  18. HERG1 K+ channels promote SDF-1-induced AML cell migration through regulation of SDF-1 level in bone marrow stromal cells. Huiyu Li, Tiannan Guo, Shenhua Jie, Hua Liu, Jiang Zhu, Lingling Fan, Wen Du, Wei Liu, Rui Cui, Shiang Huang*, Inter J Hematol. 2008, 87: 387-392

  19. Huiyu Li, Linlin Guo, Shenhua Jie, Wei Liu, Jiang Zhu, Wen Du, Lingling Fan, Xiaojun Wang, Bingjie Fu, Shiang Huang*. Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. Biomedicine and Pharmacotherapy.2008, 62:573-578

20. Xiaoqing Li, Jun Liu, Rui Zhou,Shi Huang,Shiang Huang and XianMing Chen.Gene silencing of miR-22 in acute lymphoblastic leukemia involves histone modifications independent of promoter DNA methylation. Leukemia. 2009 (submitted)

(科研办公室)