医学部系列学术讲座

题目：Molecular Mechanisms of Bile Secretion and Cholestasis

报告人：Lin Wang, M.D., Ph.D., Assistant Professor

时间：2009年4月2日（周四）下午2：30

地点：独墅湖校区炳麟图书馆720会议室

报告人简介：

工作经历：

2004-Present：Independent group leader/ Assistant Professor, Department of Medicine/Molecular Biophysics and Biochemistry/The Liver Center, Yale University

1999-2004： Associate Research Scientist, Internal Medicine/the Liver Center, Yale University

1997-1999： Postdoctoral Fellow, Center for Molecular Biology, University of Heidelberg, Germany

1993-1997： Ph.D. student, Department of Biochemistry, University of Bristol, U.K.

1991-1993： Assistant Research Scientist, Beijing Institute of Traumatology and Orthopedics, China

奖励与荣誉：

2004-2008： NIH Career Development Award (NIH, NIDDK)

1993-1996： Overseas Research Award (U.K.)

1993-1996： University Scholarship (University of Bristol, U.K.)

1991： The Best Thesis Prize, School of Basic Medical Sciences, Beijing Medical University (China)

科研项目：

2004-2008： NIH Career Development Award (DK066121, PI: Lin Wang)

2008-2010： R21 DK076919 (PI: Lin Wang) and R21 NS056999 (PI: Lin Wang)

2000-2001： Pilot grant from the Yale Liver Center (DK P30-34989)

发表文章：

1. Wang, L., Zhang, M.X. & Zheng, J. (1992): Isolation, phenotype and cytotoxicity studies of the tumour infiltrating lymphocytes (TIL) from a case of malignant osteosarcoma. Acta Traumatology and Orthopaedics 2, 102-106.

2. Wang, H.X., Yuan, R.Y., Xiang, D. & Wang L (1993) Ultra-weak luminescence of serum and urine of bone tumour patients. Chinese Journal of Oncology 15, 108-110.

3. Wang, L., Groves, J.D., Mawby, W.J. & Tanner, M.J.A. (1997) Complementation studies with co-expressed fragments of the human red cell anion transporter (band 3; AE1): the role of some exofacial loops in anion transport. J. Biol. Chem. 272, 10631-10638.

4. Groves, J.D.*, Wang, L.* & Tanner, M.J.A. (1998) The human red cell anion transporter (band3; AE1) can be assembled from several combinations of multiple fragments. FEBS Lette. 433, 223-227 (*equal contribution).

5. Groves, J.D., Wang, L. & Tanner, M.J.A. (1998) Complementation studies with co-expressed fragments of the human red cell anion transporter (band 3; AE1): the assembly of the anion transport domain in Xenopus oocyte and a cell-free translation system. Biochem. J. 332, 161-171.

6. Wang, L.* & Dobberstein B. (1999) Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lette. 457, 316-322(*corresponding author).

7. Cai, S.*, Wang L.*, Ballatori, N. and Boyer, J.L. (2001) The bile salt export pump, an ABC transporting polypeptide in liver, is highly conserved in vertebrate evolution and its expression is impaired by PFICII mutations. Am J Physiol Gastrointest Liver Physiol. 2001 281 G316-322(*equal contribution).

8. Lee, J.M., Azzoroli, F., Wang, L., Soroka, C. Kramer, W. and Boyer, J.L. (2001) Adaptive regulation of bile salt transporters in cholangiocytes and kidney in obstructive cholestasis in the rat. Gastroenterology 121, 1473-1484.

9. Wang, L.*, Soroka, C.J. and Boyer, J.L. (2002) The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. Journal of Clinical Investigation, 110, 965-972. (*corresponding author).

10. Azzaroli, F., Mehal, W. Soroka, C.J., Wang, L., Lee, J. Crispe, N. and Boyer, J.L. (2002) Ursodeoxycholic acid diminishes Fas-ligand induced apoptosis in mouse hepatocytes. Hepatology, 36, 49-54.

11. Wang, L.* and Boyer, J.L. (2004) The maintenance and generation of membrane polarity in hepatocytes. Hepatology, 39, 892-899 (*corresponding author).

12. Kreft, S.G., Wang, L. and Hochstrasser, M. (2006) Membrane topology of the yeast ERlocalized ubiquitin ligase Doa10 and comparison to its human ortholog TEB4 (MARCH-VI). J.Biol. Chem. 281, 4646-4653.

13. Arteaga, M.F., Wang, L., Ravid, T., Hochstrasser, M. and Canessa C.M. (2006) An Nterminal degradation signal in serum and glucocorticoid-induced kinase (Sgk1) targets it to the ER-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A, 103, 11178–11183.

14. Wang, L.*, Dong, H., Soroka, C.J., Wei, N., Boyer, J.L. and Hochstrasser M. (2008) The degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis. Hepatology 48, 1558-15569 (*corresponding author).