学术报告
题目：Bioinformatics analysis of molecular mechanism of microRNAs in signaling pathways and glioblastoma
报告人：徐建震
时间：2009年4月9日（周四）下午2：00
地点：苏州大学独墅湖校区403号楼一楼3119会议室
报告人简介：
徐建震，男，现为中国科学院广州生物医药与健康研究院整合生物中心在读博士。
1999年本科毕业于华南农业大学， 生物技术专业；
2006年硕士毕业于哈尔滨医科大学生物信息学学院，生物信息专业；
2009年将博士毕业于中国科学院广州生物医药与健康研究院，生物化学与分子生物学专业。
报告内容简介：
MicroRNAs (miRNAs) are one class of short, endogenous RNAs which can regulate gene expression at the post-transcriptional level.Previous analysis revealed that mammalian miRNAs tend to cluster on chromosomes. However, the functional consequences of this clustering and conservation property are largely unknown. In the first study,I present a method to identify signaling pathways targeted by clustered miRNAs. I performed a computational screen for mouse signaling pathways targeted by miRNA clusters and found 3 miRNA clusters are overrepresented in 15 signaling pathways. Experimental evidence showed that one miRNA cluster, mmu-mir-183–96–182 targets Irs1, Rasa1, and Grb2, all of which are located in the insulin signaling pathway. miRNA target prediction is a key step towards functional analysis. In the second example, i presented a procedure that combined bioinformatics analysis with biological experiment observation to predict bona fide targets. By this procedure, I found one brain enriched miRNA could target anti-apoptosis family members. Furthermore,I confirmed all the two predicted targets with experimental approaches in glioblastoma cell lines.
近年主要研究成果
[1] Liming Zhao, Ting Liang, Jianzhen Xu, Hui Lin, Dandan Li, Yanhua Qi. (2009): Two novel FBN1 gene mutations with ectopia lentis and marfanoid habitus in two Chinese families accepted in molecular vision（2007 IF=2.3）
[2] Jianzhen Xu and chiwai Wong.(2008): A computational screen for mouse signaling pathways targeted by microRNA clusters. RNA,14(7):1276-1283 (2007 IF=5.84)
[3]李永庆 徐建震 孟志刚 李永进 染色体上聚集的microRNAs具有更多共同的靶基因 生物物理学报-2007年6期（通讯作者）
[4] Jianzhen Xu and Yongjin Li.(2006): Discovering disease genes by topological features in human protein-protein interaction network. Bioinformatics,22:2800~2805 (Corresponding author) (2006 IF=4.89)
[5] Dong Wang, Yingli Lv, Zheng Guo, Xia Li, Yanhui Li, Jing Zhu, Da Yang, Jianzhen Xu, Chenguang Wang, Shaoqi Rao, and Baofeng Yang. (2006): Effects of replacing the unreliable cDNA microarray measurements on the disease classification based on gene expression profiles and functional modules. Bioinformatics,22:2883~2889 (2006 IF=4.89)
[6] Jianzhen Xu, Zheng Guo,Min Zhang, Xia Li, Yongjin Li, Shao-qi Rao. (2006): Peeling off the hidden genetic heterogeneities of cancers based on disease-relevant functional modules. Molecular Medicine 12(1–3):25-33 (2006 IF=2.7)
[7] Zheng Guo, Tianwen Zhang, Xia Li, Qi Wang, Jianzhen Xu, Hui Yu, Jing Zhu, Haiyun Wang,Topol EJ, Shaoqi Rao. (2005): Towards precise classification of cancers based on robust gene functional expression profiles. BMC Bioinformatics 6:58. (2005 IF=5.42)
[8] 徐建震 郭政 李霞 李永进 刘 帅 屠康 结合基因功能分类体系筛选聚类特征基因 生物物理学报-2005年3期
[9] 柏锡 徐建震 李 琳 郭 政 李 杰 朱延明 马铃薯密码子用法分析及其在t-PA基因密码子改造上的应用 遗传-2004年1期
(基础医学与生物科学学院)
