生物信息学术报告

题目：Molecular Modeling on the Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants

报告人：涂友斌（Youbin Tu）

时间：2009年5月7日（周四）上午10：00

地点：苏州大学独墅湖校区403号楼一楼3119会议室

报告人简介：

Research Associate Feb 2009- Present

Department of Biochemistry & Great Lakes Bioenergy Research Center

University of Wisconsin-Madison, Madison, WI, USA

Research Area: Prediction of Protein-Protein, Protein-Ligand Interactions

Graduate Training for Master Degree in Computer Sciences, May 2007 to Jan 2009

Lane Department of Computer Science and Electrical Engineering

West Virginia University, Morgantown, WV, USA

Advisor: Dr. Donald Adjeroh

Research area: Structural Bioinformatics and Computational Biology

Ph.D. in Pharmaceutical Sciences May 2008

Basic Pharmaceutical Department, School of Pharmacy,

West Virginia University, Morgantown, WV, USA

Advisor: Dr. Grazyna D. Szklarz

Research area: Computational Chemistry & Molecular Modeling

Dissertation: Functional Domains of P450 1A1 and 1A2: Molecular

Modeling-Guided Structure-Function Study

Teaching Assistant (Lecturer at 2002) Sep1999-Jul 2002

Department of Biochemistry, Medical School, Soochow University

Suzhou, Jiangsu Province, PR China

M.S. in Biophysics Jun 1999

The Institute of Plasma Physics, Chinese Academy of Sciences

Heifei, Anhui Province, PR China

B.S. in Biochemistry Jun 1996

Department of Biology, Anhui University

近年主要研究成果：

[1] Tu, Y., Deshmukh, R., Sivaneri M., Szklarz, G.D. “ The Application of Molecular

Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants”

Drug Metab Dispos 2008, 36: 2371-2380

[2] Zhang, W., Tu, Y., Yu, A. and Haining, R.L. “ Expression and Functional Analysis of

CYP2D6.24, CYP2D6.26, CYP2D6.27 and CYP2D7 Isozymes ” Drug Metab Dispos.

2009, 37: 1-4

[3] Tu, Y., Szklarz, G.D. “ Modeling aided identification and modification on CPR binding

residues of P450 1A2: The case of N145K“ submitted to Drug Metab Dispos. (2009)

[4] Tu, Y., Ericksen, S.S. and Szklarz, G. D. “Prediction of changes in specificity of

alkoxyresorufin oxidation by CYP1A2 upon site-directed mutagenesis” Drug Metab.

Rev. 2004, 36 (suppl. 1):74.