报告题目：Evolutionary genetics of coronary heart disease
报告人：丁克越 博士
报告时间：2009年5月12日（周二）下午2：30
报告地点：独墅湖校区炳麟图书馆720室
报告人简介：
丁克越，2004年毕业于中国协和医科大学基础医学院，同年在美国著名的Mayo Clinic从事博士后研究，现为Instructor of Medicine, College of Medicine, Mayo Clinic。主要研究方向为冠心病的遗传学。发表SCI署名文章20多篇，其中第一作者12篇，文章发表杂志包括Circulation, Genetic Epidemiology, Molecular Biology and Evolution ,与Bioinformatics等。
报告摘要：
Genetic variants underlying both complex and Mendelian diseases may be affected by natural selection and conversely, regions of the human genome under natural selection are likely to harbor functional loci that may influence disease susceptibility. Evolutionary forces are likely to have operated on common diseases such as coronary heart disease and inferences regarding natural selection may therefore help identify disease susceptibility loci in humans and facilitate disease-mapping studies. I present an evolutionary perspective of coronary heart disease, a major cause of morbidity and mortality in the world and discuss the current hypotheses and knowledge regarding the evolutionary genetics of several risk factors for coronary heart disease including hypertension, dyslipidemia, and the metabolic syndrome. Several candidate genes in pathways of blood pressure, glucose and lipid metabolism, blood clotting, and inflammation that may be under natural selection are enumerated. An evolutionary perspective might help explain why contemporary humans are at high risk for coronary heart disease and also better understand inter-individual variation in disease susceptibility.
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