Title：Role of the heme-heme oxygenase system in vasomotor control
报告人：Frank Zhang 教授
地点：苏州大学独墅湖校区医学楼403-3119 会议室
时间：2009年5月17号下午14:00
报告人简介：
Frank Zhang，1995年毕业于英国Sheffield大学，获药理学博士学位，1995-1997年在纽约Will Rogers Pulmonary Res. Lab.做博士后研究，现为纽约大学医学院药理学系Assistant Professor,四川大学教授，主要从事心血管药理学研究工作，多次获美国心肺协会基金资助，在Hypertension，Am J Physiol，Circ Res, Circulation等SCI杂志发表论文20多篇。
主要代表作如下：
1. Zhang F, Kaminski PM, Lamon B, Wolin MS, Nasjletti A. Environmental Carbon Monoxide is a Determinant of Oxidative Stress and Defective Relaxing Responsiveness to Acetylcholine.
Hypertension, 2006;48 (4): e55.
2. Zhang F, Kaide JI, Yang L, Jiang H, Quan S, Kemp R, Gong W, Balazy M, Abraham NG, Nasjletti A. CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin.
Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H137-44. Epub 2003 Sep 11.
3. Kruger AL, Peterson S, Turkseven S, Kaminski PM, Zhang FF, Quan S, Wolin MS, Abraham NG D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial ­ PHS 398/2590 (Rev. 05/01) Page _______ Biographical Sketch Format Page ­
cell sloughing, and improves vascular reactivity in rat model of diabetes. Circulation. 2005 Jun
14;111(23):3126-34. Epub 2005 Jun 6.
4. Zhang F, Deng H, Kemp R, Singh H, Gopal VR, Falck JR, Laniado-Schwartzman M, Nasjletti A. Decreased Levels of Cytochrome P450 2E1-Derived Eicosanoids Sensitize Renal Arteries to
Constrictor Agonists in Spontaneously Hypertensive Rats. Hypertension. 2005 Jan;45(1):103-8.
Epub 2004 Nov 29.
5. Zhang F, Wang MH, Wang JS, Zand B, Gopal VR, Falck JR, Laniado-Schwartzman M, Nasjletti A. Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli. Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1089-95. Epub 2004 May 06.
6. Zhang F, Kaide JI, Wei Y, Jiang H, Yu CH, Balazy M, Abraham NG, Wang WH and Nasjletti A. Carbon monoxide produced by isolated arterioles attenuates pressure-induced vasoconstriction. Am J Physiol., 2001; 281: H350.
7. Zhang F, Kaide JI, Rodriguez-Mulero F, Abraham NG and Nasjletti A. Vasoregulatory function of heme-heme oxygenase-carbon monoxide system. Am J Hypertension, 2001; 14: 62S-67S.
8. Kaide JI, Zhang F, Wei Y, Jiang H, Yu CH, Wang WH, Balazy M, Abraham NG and Nasjletti A.
Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial to vasoconstrictors.
J. Clin. Invest. 2001; 107: 1163-1171.
9. Rapacon-Baker M, Zhang F, Pucci, ML, Guan H and Nasjletti A. Expression of myogenic constrictor tone in the aorta of hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2001
Apr;280(4):R968-75..
10. Wang MH, Zhang F, Marji J, Zand BA, Nasjletti A and Schwartzman ML. CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. Am J Physiol Regulatory Integrative Comp Physiol 280; R255-R261, 2001.
11. Kaide J, Zhang F, Wei Y, Wang W, Gopal VR, Falck JR, Laniado-Schwartzman M, Nasjletti A. Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced
vasoconstriction. Hypertension. 2004 Aug;44(2):210-6. Epub 2004 Jun.
12. Brodsky SV, Zhang F, Nasjletti A, Goligorsky MS. Endothelium-derived Microparticles Impair Endothelial Function in Vitro. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1910-5.
13. Brodsky SV, Gealekman O, Chen J, Zhang F, Togashi N, Crabtree M, Gross SS, Nasjletti A,
Goligorsky MS. Prevention and Reversal of Premature Endothelial Cell Senescence and
Vasculopathy in Obesity-Induced Diabetes by Ebselen. Circ Res. 2004 Feb 20;94(3):377-84.
Epub 2003 Dec 11.
14. Wang JS, Zhang F, Jiang M, Wang MH, Zand BA, Abraham NG, Nasjletti A, Laniado-Schwartzman M. Transfection and Functional Expression of CYP4A1 and CYP4A2
Using Bicistronic Vectors in Vascular Cells and Tissues. J Pharmacol Exp Ther. 2004 Jul 21.
15. Zhang F, Wang MH, Schwartzman ML and Nasjlettti A. Role of 20-HETE in the implementation of agonist-induced tone in small and large mesenteric arteries. Hypertension, 1998; 32(5):2.
16. Zhang F, Morice AH. The effect of lemakalim on hypoxic, KCl and PGF2a induced contractions in isolated rat pulmonary artery. J Pharmacol Exp Ther. 1994; 271(1): 326-33
17. Zhang F, Carson RC, and Thomas HM III. Effects of graded hypoxia on contraction of pulmonary and mesenteric artery smooth muscle cells. Circulation, 1995; 92 (8): I-700-701.
18. Zhang F, Woodmansey PA and Morice AH. Acute hypoxic vasoconstriction in isolated rat small and large pulmonary arteries. J Physiol. Res. 1995, 44: 7-18.
19. Zhang F, Carson RC, Zhang H, Gibson G and Thomas HM III. Pulmonary artery smooth muscle cell contraction and intracellular calcium: responses to diphenyleneionium and hypoxia. Am. J. Physiol. 1997; 273 (Lung Cell. Mol. Physiol. 17): L603-611.
20. Zhang F, Carson RC, Su M and Thomas HM III. Effects of potassium channel blockers on
hypoxia-induced contraction of pulmonary arterial smooth muscle cells (PASMC). Am. J. of Respir. Crit. Care. Med. 1997; 155(4): A792.
(基础医学与生物科学学院)
