Title:THE POLYSIALIC ACID GLYCOTOPE AND ITS IMPORTANCE IN NEURODEVELOPMENT AND CANCER METASTASIS.
（唾液酸与神经发育及肿瘤转移）
报告人： PROFESSOR FREDERIC A. TROY II
University of California School of Medicine
Department of Biochemistry & Molecular
Medicine and Member,
UC Davis Cancer Center
Davis, CA USA
Dr. BING WANG
Human Nutrition Unit School of Molecular &
Microbial School of Molecular & Microbial Biosciences
时 间：2009年10月22日 下午15：00
地 点：独墅湖校区炳麟图书馆825会议室
2009.10.19
附1：报告人简介
PROFESSOR FREDERIC A. TROY II and Dr. BING WANG are Senior Research Scientists, Cognitive Neuroscience Group, Nutrition and Health Department. The overall goal of “Molecular Neurobiology/-Nutritional Research Program” is to elucidate the molecular basis of how nutrient components alter metabolic responses important to human health. The major focus is in the area of neural and cognitive development, memory and CNS development in health and disease.
International Journal Reviewer
1. American Journal of Clinical Nutrition
2. Comparative Biochemistry and Physiology
3. Journal of Pediatric Gastroenterology and Nutrition
4. Journal of Molecular evolution
5. British Journal of Nutrition
6. Nutrition & Dietetics
7. International Dairy Journal
AD HOC REVIEWER (LAST 5 YEARS) FOR:
Proceedings of the National Academy of Sciences; Biochemistry; Science; Journal of Organic Chemistry; Glycoconjugate Journal; European Journal of Biochemistry; Biotechnology and Bioengineering; Analytical Biochemistry; Biophysical Journal; Journal of Carbohydrate Chemistry and Plos One.
附2：ABSTRACT
Polysialic acid (polySia) is an oncodevelopmental, tumor-associated, anti-adhesive glycotope that covalently modifies N-linked glycans on neural cell adhesion molecules (N-CAMs). These structurally unique cell surface sugar chains are best know for their key role in modulating cell-cell interactions, principally during neuronal development, neural plasticity, and tumor metastasis.
Key concepts to be described in this seminar will include: (1) What is polysialic acid and why it is important in molecular medicine?; (2) How to accurately determine the length of polySia chains ; (3) The molecular basis of polysialylation; and (4) the role of polySia in neurodevelopment and cancer metastasis.
(科研办公室)
