基础医学与生物科学学院学术报告：脂肪细胞的发育

报告题目: 脂肪细胞的发育

报告时间: 2010年6月28日上午9时30分

报告地点: 医学楼3119室

报告人简介:

汤其群博士，教育部“长江学者奖励计划”特聘教授（1999），国家“杰出青年基金”获得者（2007），国家重大科学研究计划“干细胞定向分化的基础和临床应用研究”首席科学家（2007）。

学习与工作经历：

1990年毕业于上海医科大学法医学专业，获医学学士学位；1995年毕业于上海医科大学生物化学与分子生物学系获理学博士学位；1995-1997在Johns Hopkins大学医学院生物化学系完成博士后工作，1997-2002担任Research Associate 和讲师，2002年被聘为儿科内分泌助理教授兼生物化学系助理教授；2005年6月全职回国。目前担任“分子医学教育部重点实验室”主任，复旦大学上海医学院“生物化学与分子生物学系”系主任，为复旦大学上海医学院科研副院长，复旦大学生物医学研究院科研副院长，干细胞与再生医学研究所所长。主要从事脂肪细胞发育分化的分子机理研究，尤其是干细胞如何定向为前脂肪细胞的机理及其与相关疾病的关系研究。

目前主持课题：

1、脂肪细胞发育分化的机理与相关疾病的关系研究

编号：30625015 经费200万 2007.1-2010.12 国家杰出青年基金 课题负责人;

2、干细胞定向分化的基础与临床应用研究

编号： 2006CB943700 经费2100万 2006.12－2010.12

近三年发表文章:

1. Haiyan Huang，Tan-Jing Song, Xi Li, Lingling Hu, Qun He, Mei Liu, M. Daniel Lane, and Qi-Qun Tang, (2009) BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA. 106:12670-5

2. Xi Li, Henrik Molina, Haiyan Huang, You-you Zhang, Mei Liu, Shu-wen Qian, Chad Slawson, Wagner B. Dias, Akhilesh Pandey, Gerald W. Hart, M. Daniel Lane, and Qi-Qun Tang.(2009)O-linked N-acetylglucosamine modification on CCAAT Enhancer-binding protein b: Role during adipocyte differentiation. J. Biol.Chem.284:19248-19254

3. Henrik Molina, Yi Yang, Ruch T, Kim JW, Mortensen P, Otto T, Nalli A, Qi-Qun Tang, Lane MD, Chaerkady R, Pandey A(2009).Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy. J Proteome Res. 8:48-58

4. Haiyan Huang, Xi Li, Mei Liu, Tan-Jing Song, Qun He, Chun-gu Ma, Qi-Qun Tang (2008). Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression. Biochem Biophys Res Commun. 375:496-500

5. Deguo Liu, Honglei Liu, Tanjing Song, Haiyan Huang, Xi Li, Qi-Qun Tang, (2007) Functional expression of the globular domain of human adiponectin in Pichia pastoris. Biochem Biophys Res Commun. 363(3):769-775

6. Zuochun Peng, Xu Cai, Zhang YG, Desheng Kong, Hongshen Guo, Wang Liang, Qi-Qun Tang, Houyan Song, Duan Ma, A novel anti-tissue factor monoclonal antibody with anticoagulant potency derived from synthesized multiple antigenic peptide through blocking FX combination with TF. Thromb Res. 2007 121 (1): 85-93

7. Yifeng Lin, Nong Zhang, Hongshen Guo, Desheng Kong, Jiang T, Wang Liang, Zhao ZH, Qi-Qun Tang, Duan Ma, Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway. Apoptosis. 2007 12 (12 ): 2163-73 .

8. Xi Li, Jae-Woo Kim, Mads Gronborg, Henning Urlaub，M Daniel Lane, Qi-Qun Tang, (2007) Role od cdk2 in the Sequential Phosphorylation/activation of C/EBPb during adipocyte differentiation. Proc Natl Acad Sci USA. 104: 11597-602

9. Jianyong Liu, Heather Martin, Meir Shamay, Crystal Woodard, Qi-Qun Tang, S. Diane Hayward, (2007) Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation. J Virol 81: 4722-4731

10. Jae-Woo Kim, Qi-Qun Tang, Xi Li, M Daniel Lane, (2007) DNA binding and transcriptional activation by C/EBP beta: effect of phosphorylation and S-S bond-induced dimerization. Proc Natl Acad Sci USA. 104: 1800-4