报告题目：The zebrafish model in liver cancer and toxicogenomics
报告人: Gong Ziyuan教授
报告时间: 2010年9月29日 上午9:00
报告地点: 苏州大学独墅湖校区炳麟图书馆820会议室
报告人简介：
Gong ziyuan, 男，博士，新加坡国立大学生物系教授，新加坡国立大学研究生院教授，新加坡-麻省理工SMA成员，厦门大学、海南大学客座教授，哈尔滨水产研究所客座研究员。
Gong 教授长期从事斑马鱼发育生物学、基因组学及鱼类毒理学研究，在斑马鱼转基因及鱼类发育遗传学等多方面取得了世界领先的成果，所建立的Glo转基因鱼是目前世界上唯一在市场能够买到的转基因鱼。在Nature genetics, Nature Biotechnology, PloS Genetics, molecular cell biology, Developmental biology, EMBO Journal, JBC, FEBS, oncogene, BMC Genomics, PloS One等国际知名学术刊物上发表专业研究论文130多篇。
近三年主要代表论文：
1、Zhu, S., L. Liu, V. Korzh, Z. Gong and B.C. Low (2007) RhoA prevents apoptosis during zebrafish embryogenesis through activation of Mek/Erk pathway. Oncogene. 27:1580-1589. （并列通讯作者）
2、Li. Z., V. Korzh and Z. Gong (2007) Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development. BMC Dev Biol. 7:117.
3、Wu, Y.L., X. Pan, H. Wang, P.W. Kee, S.P. Mudumana and Z. Gong (2007) Development of a heat shock inducible gfp transgenic zebrafish line by using the zebrafish hsp27 promoter. Gene. 408:85-94.
4、Lam, S.H, Y.L. Wu, V.B. Vega, L.D. Miller, J. Spitsbergen, Y. Tong, H. Zhan, K. R. Govind a rajan, S. Lee, S. Mathavan, D.R. Buhler, E.T. Liu, and Z. Gong. Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nature Biotechnology 24: 73-75
5、Pan X, Zhan H, Gong Z. (2008) Ornamental Expression of Red Fluorescent Protein in Transgenic Founders of White Skirt Tetra (Gymnocorymbus ternetzi). Mar Biotechnol 10:497-501
6、Lam, SH, Mathavan S, Tong Y, Li H, Karuturi RKM, Wu YL, Vega VB, Liu ET and Gong Z. (2008) Zebrafish Whole-Adult-Organism Chemogenomics for Large-Scale Predictive and Discovery Chemical Biology. PLOS Genetics. 4:e1000121
7、Liu, L.,
8、Liu, X., Z. Li, A. Emelyanov, S. Parinov and Z. Gong (2008) Generation of oocyte-specifically expressed cre transgenic zebrafish for female germline excision of loxP-flanked transgene. Dev. Dyn. 237:2955-2962
9、Korzh, S., X. Pan, M. Garcia-Lecea, C.L. Winata, X.T. Pan, T. Wohland, V. Korzh and Z. Gong (2008) Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Dev Biol. 8:84
10、Li, Z., C. Wen, J. Peng, V. Korzh and Z. Gong (2009) Generation of living color transgenic zebrafish to trace somatostatin-expressing cells and endocrine pancreas organization. Differentiation 77:128-134
11、Winata CL, Korzh S, Kondrychyn I, Zheng W, Korzh V, Gong Z. (2009) Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Dev. Biol. 331:222-36
12、Li, Z., V. Korzh and Z. Gong (2009) DTA-mediated targeted ablation revealed differential interdependence of endocrine cell lineages in early development of zebrafish pancreas. Differentiation. 78:241-252
13、Zhan, H. and Z. Gong (2009) Delayed and Restricted Expression of UAS-Regulated GFP Gene in Early Transgenic Zebrafish Embryos by Using the GAL4/UAS System. Marine Biotech. 12:1-7
14、Ung CY, Lam SH, Gong Z. (2009) Comparative transcriptome analyses revealed conserved biological and transcription factor target modules between the zebrafish and human tumors. Zebrafish 6(4):425-431
15、Winata CL, Korzh S, Kondrychyn I, Korzh V, Gong Z. (2010) The role of vasculature and blood circulation in zebrafish swimbladder development. BMC Dev Biol 10:3
16、Ung CY, Lam SH, Hlaing MM, Winata CL, Korzh S, Mathavan S, Gong Z. (2010) Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics 11(1):212
17、Sukardi, H., C.Y. Ung, S.H. Lam and Z. Gong (2010) Incorporating zebrafish omics into chemical biology and toxicology. Zebrafih 7(1):41-52.
18、Wang Z, Du J, Lam SH, Mathavan S, Matsudaira P, Gong Z. (2010) Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics 11:392
(基础医学与生物科学学院)
