药学院学术报告

时间：2010年12月6日（周一）14:00

地点：独墅湖校区二期云轩楼1319

14:00-15:00

报告题目：中药质量控制方法及其活性组分筛选研究

报告人：曹君（浙江大学 博士后）

15:00-16:00

报告题目：黄连解毒汤及其有效成分小檗碱对类胰高血糖素样肽-1的调控及机制研究

报告人：俞蕴莉（中国药科大学 博士）

16:00-17:00

报告题目：Oxidative entry to alpha-Oxy-N-Acyl Aminals: Total Synthesis of Psymberin and Its SAR study

报告人简历：Dr. Ning Shao

附：Dr. Ning Shao简介

2008-Present 　Merck， Senior Scientist，USA

2005-2007　 Schering-Plough Research Institute， Senior Scientist，USA

Total Synthesis of Anti-tumor Natural Product Psymberin and its analogues

2000-2005 Case Western Reserve University，Ph.D., 　USA

Total synthesis of biologically significant oligosaccharides and glycopeptides

1993-2000　 Sichuan University, B.S. and M.S., Sichuan, China

代表性著作：

1. Shao, N.; Huang, X.; Palani, A.; Aslanian, R.; Buevich, A.; Piwinski, J.; Huryk, R.; Seidel-Dugan, C. “New Application of PhI(OAc)2 in Synthesis: The Total Synthesis and SAR Development of Potent Antitumor Natural Product Psymberin/Irciniastatin A.” Synthesis 2009, 17, 2855-2872.

2. Huang, X.*; Shao, N.; Palani, A.; Aslanian, R.; Buevich, A. “The Discovery of Potent Anti-tumor Agent C11-Deoxypsymberin/Irciniastatin A: Total Synthesis and Biology of Advanced Psymberin Analogs.” Org. Lett. 2009, 11(4), 867–870.

3. Huang, X.*; Shao, N.; Palani, A.; Aslanian, R.; Buevich, A.; Seidel-Dugan, C.; Huryk, R. “Synthesis of seco- Psymberin/Irciniastatin A: The Discovery of a Novel PhI(OAc)₂ Mediated Casade Cyclisation Reaction.” Tetrahedron Lett. 2008, 49(22), 3592-3595

4. Huang, X.*; Shao, N.; Palani, A.; Aslanian, R.; Buevich, A. “The total synthesis of Psymberin.” Org. Lett. 2007, 9(13), 2597-2600.

5. Huang, X.*; Shao, N.; Palani, A.; Aslanian, R. “Oxidative entry to α-oxy N-acyl aminals and hemiaminals: efficient formation of 2-(N-acylaminal) substituted tetrahydropyrans.” Tetrahedron Lett. 2007, 48(11), 1967-1971.