基础医学与生物科学学院学术报告

发布者：系统管理员发布时间：2011-03-31浏览次数：3166


报告题目：Antibody engineering: using yeast  display technology

报告人: Bailin Tu博士

报告时间: 2011年4月4日9:00-10：30AM

报告地点: 苏州大学独墅湖校区703楼631会议室

Bailin Tu, Ph.D. ，雅培诊断抗体研究部门首席科学家。1985年在河南医科大学医学院获M.D.。1988年在首都医学研究所细胞生物学系获M.S.。1994年在中国医学科学院&北京协和医学院基础医学研究所获生物物理与生物化学专业博士学位。1994年至2000年先后在威斯康辛-麦迪逊大学遗传学研究中心和乔治亚医学院 分子医学与遗传研究所进行博士后研究。曾作为美国FDA首席科学家及团队负责人制定了FDA2003年质量控制系统免疫测定标准。2000年以来，Dr. Tu的主要研究方向为抗体工程。领导并完成了包括anti-BNP 和anti-HCV等多项抗体工程的研发与应用。已经在Nature genetics, Clinical and Vaccine immunology, JBC, Molecular cell biology等国际一流杂志上发表了数十篇论文，获得美国发明专利10项。

主要代表论文：

  1. Bailin Tu, Robert Ziemann, Susan Brophy, Robert Siegel, Ryan Workman, Salman Ali, Felicia Bogdan, Frank Grenier, Engineering and characterization of human Neutrophil Gelatinase-associated Lipocalin (hNGAL) for immunoassay, Biochemical and Biophysical Research Communications, submitted 2011
  2. Xiaoxing Qiu, Priscilla Swanson, Ka-Cheung Luk, Bailin Tu, Francois Villinger, Jaydip Das Gupta, Robert H Silverman, Eric A Klein, Sushil Devare, Gerald Schochetman, John Hackett Jr., Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies, Retrovirology 2010, 7:68
  3. Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, David J. Hawksworth, Joan Tyner, James Scheffel, Mary S. Pinkus, Susan E. Brophy, Jeffrey M. Werneke, Robin Gutierrez, and Michael White, Generation and Characterization of Chimeric Antibodies Against NS3, NS4, NS5 and Core of Hepatitis C Virus, Clinical and Vaccine immunology 2010, 17(6):1040-1047.
  4. Mo, X., Bailin, T., Sadofsky, M. J., A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination, Mol. Cell Biol. 2001 21(6): 2038-47.

5. Mo, X., Bailin, T., Noggle, S., Sadofsky, M. J., A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1, Nucleic Acid Research. 2000, 28(5):1228-1236

6. Bailin, T., MO, X., Sadofsky, M. J., A RAG1 and RAG2 tetramer complex is active in cleavage in V(D) J recombination, Mol Cell Biol 1999, 19(7): 4664-4671

7. Mo, X., Bailin, T., Sadofsky, M. J., RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro, J. Biol. Chem. 1999, 274(11): 7025- 7031

8. Bailin, T., Oh, J., Feng, G., Spritz, R. A., Organization and Nucleotide sequence of the Human Hermansky-Pudlak syndrome (HPS) gene, J. Invest Dermatol. 1997,108: 923-927

9. Sviderskaya, E. V., Bennet, D. C., Ho, L., Bailin, T, Lee, S., Spritz, R. A., Complementation of hypopigmentation in p-mutant mouse melanocytes by normal but not OCA2 mutant human p cDNA, J Invest Dermatol. 1997, 108: 30-34

10.Spritz, R. A., Bailin, T., Lee, S., Park, S., Nicholls, R. D., Mascari, M. J., Butler, M. G., Hypopigmentation in the Prader-Willi syndrome correlates with P gene but not with haplotype of the hemizygous P allele, Am. J. Med Genetics. 1997, 71: 57-62

11.Feng, GH., Bailin, T., Oh, J., Spritz, R. A., Mouse `Pale-ear` is homologue to Hermansky-Pudlak syndrome, Human Mol Genetics 1997, 6: 793-797

12.Oh, J., Bailin, T., Fukai, K., Feng, GH., Mao, JI., Frenk, E., Almodovar, C., Tamura, N., SpritzR. A., A gene for Hermansky-Pudlak Syndrome, a disorder of cytoplasmic organelles, Nature Genetics. 1996, 14:300-306

13.Bailin, T., Lee, S., Spritz R. A., Genomic organization and sequence of D12S53E (P mel17), the human homologue of the mouse silver (si) locus, J. invest. Dermatol. 1996,106:24-26

14.Zhou, F., Bailin, T., Lee, K., Si, GY., Liu ,S., Detection of multiple HPV by PCR with consensus primers in the cervical cancer. Chinese J. Microbio Immunol. 1993, 13:320

15.Bailin, T., Si, GY., The HPV in the carcinogenesis of cervical carcinoma, Advances in the Med. p28-40, 1993. Shanghai Sci Tech press.

16.Wan, E., Bailin, T., Kuen, Y. Toxicity of coal dusts on the alveolar macrophage. J North China Coal Med. 1993, 8(2): 4-16

17.Bailin, T., Yu, M., Morphological and cytochemistry study on the secretary mechanism of alveolar macrophages, J North China Coal Med 1990, 5(2):11-14

18.Bailin, T., Wan, E., Comparative study of quantitative cytochemistry of BCG activated alveolar macrophages with that of peritoneal macrophages, Acta Anatomic Sinica. 1989, 20:76

(基础医学与生物科学学院)