报告题目：Rational Design of Antibiotics for Tuberculosis
报 告 人： Courtney Aldrich博士（美国明尼苏达大学药物设计中心）
报告时间：
报告地点：独墅湖校区二期药学院云轩楼1319
报告人简介：
Courtney Aldrich博士系美国明尼苏达大学（University of Minnesota）,药物设计中心副主任。1994年毕业于密苏里大学（University of Missouri）,获学士学位；2000年毕业于加利弗尼亚，洛杉矶分校，获博士学位。
List of publications:
1. Drake, E. J.; Duckworth, B. P.; Neres, J.; Aldrich, C. C.; Gulick, A. M. Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Non-ribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis. Biochemistry 2010, 49, 9292–9305.
2. Vasan, M.; Neres, J.; Williams, J.; Wilson, D. J.; Teitelbaum, A. M.; Remmel, R. P.; Aldrich, C. C. Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening. Chemmedchem 2010, 5, 2079–2087.
3. Wilson, D. J.; Aldrich, C. C. A Continuous Kinetic Assay for Adenylation Enzyme Activity and Inhibition. Anal. Biochem. 2010, 404, 56-63.
4. Chen, L.; Wilson, D. J.; Xu, Y.; Aldrich, C. C.; Felczak, K.; Sham, Y. Y.; Pankiewicz, K. W. Triazole-linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and Mycobacterium tuberculosis. J. Med. Chem. 2010, 53, 4768-4778.
5. Duckworth, B. P.; Aldrich, C. C. Development of a High-Throughput Fluorescence Polarization Assay for the Discovery of Phosphopantetheinyl Transferase Inhibitors. Anal. Biochem. 2010, 403, 13-19.
6. Shi, C.; Aldrich, C. C. Efficient Pd-Catalyzed Coupling of Tautomerizable Heterocycles with Terminal Alkynes via C-OH Bond Activation Using PyBroP. Org. Lett. 2010, 12, 2286-2289.
7. Sikora, A. L.; Wilson, D. J.; Aldrich, C. C.; Blanchard, J. S. Kinetic and Inhibition Studies of Dihydroxybenzoate-AMP Ligase (EntE) from Escherichia coli. Biochemistry 2010, 49, 3648-3657.
8. Duckworth, B. P.; Aldrich, C. C. Assigning Enzyme Function from the Metabolic Milieu. Chem. Biol. 2010, 17, 313-314.
9. Grimes, K. D.; Gupte, A.; Aldrich, C. C. Copper(II)-Catalyzed Conversion of Aryl/Heteroaryl Boronic acids, -Boronates, and –Trifluoroboronates to the Corresponding Azides: Substrate Scope and Limitations. Synthesis 2010, 1441-1448.
10. Aldrich, C. C.; Boshoff, H. I.; Remmel, R. P. Antitubercular Agents. In Burgers Medicinal Chemistry, 7th Edition; Eds. Rotella, D.; Abraham, D. J.; Wiley, 2010; 713-812.
(药学院)
