生物钟研究中心学术报告

报告题目：Chemical Genetics of Hematopoietic Stem Cell Transplantation

报 告 人：Yi Zhou, PhD, Instructor in Pediatrics at Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts.

报告时间：2012年7月24日（周二） 1:30-2:30PM

报告地点：703楼1楼生物钟研究中心会议室

报告人简介：Yi Zhou obtained his bachelor degree form Sichuan University in 1984; and his master degree from Department of Biology in Graduate School of Chinese Academy of Sciences and the University of Science and Technology of China in 1987; then he received his doctoral degree in Cell Biology in University of Miami in 1995. In 1995-1996, Dr. Zhou worked as a research associate in Dr. Merietta Lee’s Lab, University of Miami School of Medicine. In 1996-1998, he worked as a postdoctoral fellow in Dr. Leonard I. Zon lab, Division of Hematology and Oncology, Children’s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA. He currently is an Instructor in Pediatrics at Children’s Hospital Boston, Harvard Medical School and Director of the Genomics Core of the Stem Cell Program at Children's Hospital Boston.

Dr. Zhou’s main research interests are as follow:

1. Functional genomics and epigenetics

2. Hematopoiesis during vertebrate development

3. Stem cell biology

4. Vertebrate body patterning during embryonic development

5. Functions of localized mRNAs and mechanisms of mRNA localization

代表论文：

1. de Jong JL, Burns CE, Chen AT, Pugach E, Mayhall EA, Smith AC, Feldman HA, Zhou Y, Zon LI. (2011) Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 117(16):4234-42.

2. Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT. (2011) cpsf1 is required for definitive HSC survival in zebrafish. Blood. 117(15):3996-4007.

3. Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI.(2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell 142(1):133-43.

4. Trede NS, Medenbach J, Damianov A, Hung LH, Weber GJ, Paw BH, Zhou Y, Hersey C, Zapata A, Keefe M, Barut BA, Stuart AB, Katz T, Amemiya CT, Zon LI, Bindereif A. (2007) Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A. 104(16):6608-13.

5. Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH. (2006) Mitoferrin is essential for erythroid iron assimilation. Nature. 2006 440(7080):96-100.