报告题目：Local protein translation in axons
报 告 人: 姬生健 博士，Weill Medical College，Cornell University
报告时间: 2013年3月25日（周一）上午10：00
报告地点: 苏州大学神经科学研究所会议室
报告摘要：
Neuronal specification is fundamental for proper assembly of neuronal circuits. While pre-specified genetic programs play important roles in the early steps of neuronal specification, many neurons acquire distinct identities as their axons navigate toward target cells and encounter target-derived signaling molecules. Mechanisms by which axons convert the complex milieu of signaling molecules into retrograde signals are not fully understood.
In this seminar, Dr. Ji will discuss the experimental evidence that supports a role for axonally derived transcription factors in neuronal specification. We find that neuronal specification in trigeminal ganglia requires the sequential action of two target-derived factors, BDNF and BMP4. BDNF induces the translation of axonally localized SMAD1/5/8 transcripts. Axon-derived transcription factors SMAD1/5/8 are then translocated to the cell body, where it is phosphorylated to a transcriptionally active form by BMP4-induced signaling endosomes. Our data raise the intriguing possibility that the axonal translation and retrograde trafficking of transcription factors may be a recurrent feature in neuronal subtype specification and patterning.
神经科学研究所
2013-03-20
(科研办公室)
