报告题目：Leaky calcium channels: novel causes and cures for diseases of heart, muscle and brain
报告人：Andrew R. Marks教授
报告时间：2013年5月30日15:30-16:30
报告地点：独墅湖校区703楼5楼学术报告厅
Andrew R. Marks教授简介
Andrew R. Marks，哥伦比亚大学生理及细胞生物物理学系教授（Department of Physiology and Cellular Biophysics），哥伦比亚长老会医学中心主治医师（Columbia-Presbyterian Medical Center），美国科学院院士。
Dr. Marks1976年毕业于Amherst大学，取得生物学与英语学士学位，1985年获得哈佛大学医学院博士学位。主要研究方向包括：钙离子通道的结构和功能、心血管系统跨膜信号传递、兴奋收缩耦联的分子生物学研究、心力衰竭及心脏性猝死的分子生物学研究、心血管系统的细胞周期调控等。
先后主持美国国家级科研课题近30项，包括国立卫生研究院（NIH）、国家心肺血液研究所（NHLBI）、美国心脏协会（American Heart Association）等机构的科研项目。在Science, Circulation, Circulation Research以及PNAS等国际顶尖学术刊物发表论文120余篇，取得研究专利8项，出席国际学术会议并作学术报告近200场。曾经担任The Journal of Clinical Investigation杂志主编，以及Circulation，The Journal of Biological Chemistry，Circulation Research等杂志编辑，Nature, Nature Structural Biology, Nature Cell Biology, Cell, Science, Neuron等杂志审稿人 。
代表性论文：
Liu, X., Betzenhauser, M.J., Reiken, S., Meli, A.C., Arancio, O., Chen B.-X., Marks AR (2012) Role of Leaky Neuronal Ryanodine Receptors in Stress-Induced Cognitive Dysfunction Cell 150, 1055–1067.
Shan, J., Xie, W., Betzenhauser, M., Reiken, Chen, B-X, Wronska, A., Marks A.R. (2012) Calcium Leak Through Ryanodine Receptors Leads To Atrial Fibrillation In Three Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia Circulation Research 111:708-717.
Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS. (2011) Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes FASEB J. 26(3):1009-17
Lehnart S, Marks AR. Regulation of ryanodine receptors in the heart. Circ Res. 2007 Oct12;101(8):746-9
Fauconnier, J., Thireau, J., Reiken, S., Cassan, C., Richard, S., Matecki, S., Marks, A.R., Lacampagne, A. (2010) Leaky RyR2 trigger ventricular arrhythmias in Duchenne Muscular Dystrophy PNAS 107(4):1559-64. PMCID: PMC2824377
Bellinger, AM, Reiken, S, Carlson, C, Mongillo, M, Liu, X, Rothman, L, Matecki, S, LaCampagne,A, and Marks, AR (2009) Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle Nature Medicine 15:325-330. PMCID: PMC2910579
Shan, J, Nguyen, TB, Totary-Jain, H, Dansky, H, Marx, SO, and Marks, AR (2008) Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors PNAS 105(48):19006-19011. Epub2008 Nov 19. PMCID: PMC2585045
Lehnart, S., Wehrens, X., Reiken, S., Warrier, S., Belevych, AE, Harvey, RD, Richter, W., Jin, S.-L. C., Conti, M., and Marks, A.R. (2005) Phosphodiesterase 4D deficiency in the ryanodine receptor complex promotes heart failure and arrhythmias Cell 123:25-35.
Lehnart SE, Wehrens XH, Marks AR. (2005) Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.Circulation. 111(25):3342-6.
Ward CW, Reiken S, Marks AR, Marty I, Vassort G, Lacampagne A. (2003) Defects in ryanodine receptor calcium release in skeletal muscle from postmyocardial infarcted rats. FASEB J 17:1517-9
Marks A.R., Priori S., Memmi M., Kontula K., Laitinen P.J., (2002) Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular
tachycardia. J Cell Physiol 190:1-6.
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