报告题目：From construction to function: learning how the brain works using zebrafish
报告人：郭苏教授 加州大学旧金山分校
报告时间：2014年7月28日10:00 AM
报告地点：苏州大学独墅湖校区生科楼703楼一楼东会议室
郭苏教授简介：1970年生，1991年复旦大学遗传系本科毕业，1996年获得美国康奈尔大学博士学位，1996-1997年在哈佛大学医学院做医学研究员，1997-2000 年在美国基因泰克公司从事博士后工作。2001年起任加州大学旧金山分校生物工程与治疗科学系助理教授，副教授，教授。已在在Nature、Cell、Neuron以及PNAS等国际顶尖学术刊物发表论文50余篇。郭苏教授主要研究方向为：体内干细胞形态与功能和癌症及器官再生的相关性；神经网络的发育与功能及行为调控。
代表性论文：
Sun, Y., Dong, Z., Jin, T., Ang, K., Huang, M., Haston, K., Peng, J., Zhong, T., Finkbeiner, S., Weiss, W.A., Arkin, M., Jan, L.Y., Guo, S. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife 2:e00508.
Dong, Z., Yang, N., Yeo, S., Chitnis, A., and Guo, S. (2012) Intra-lineage Directional Notch Signaling Regulates Self-renewal and Differentiation of Asymmetrically Dividing Radial Glia. Neuron 74: 65-78.
Yu, W., Sun, Y., Guo, S., and Lu, B. (2011) The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum. Mol. Genet.20, 3227-40.
Lau, B., Mathur, P., Gould, G., and Guo, S. (2011) Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc. Natl. Acad. Sci. 108: 2581-6. PMCID: PMC3038752.
Jeong, J., Einhorn, Z., Mathur, P., Chen, L., Lee, S., Kawakami, K., and Guo, S. (2007) Patterning the zebrafish diencephalon by the conserved zinc finger protein Fezl. Development 134, 127-136.
Guo, S., Y. Yamaguchi, S. Schilbach, T. Wada, A. Goddard, J. Lee, D. French, H. Handa, and A. Rosenthal (2000). A regulator of transcriptional elongation, which is required for vertebrate neuronal development. Nature 408, 366-369.
Guo, S., and K. J. Kemphues. (1996). A nonmuscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature 382: 455-458.
Guo, S., and K. J. Kemphues. (1995). par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative serine/threonine kinase that is asymmetrically distributed. Cell 81: 611-620.
(科研办公室)
