Title：Matrix interactions control lung repair and fibrosis: – A sugar effect Presenter：Dianhua Jiang, Ph.D. Research Scientist III/Professor, Cedars-Sinai Medical Center Department of Medicine, Los Angeles, CA
Education
?1984-08, Bachelor of Medicine, Shandong Medical University, Ji’nan, P. R. China
?1996-12, Ph.D., Medical University of Ohio, Toledo, OH
Research Description The current proposal is to investigate the role of β-arrestins in regulating lung inflammation and fibrosis. Specifically, This proposal focuses on elucidating the roles of β-arrestins (βarr1 and βarr2) in regulating lung inflammation and fibrosis and determining the feasibility that targeting β-arrestins as a novel therapeutic approach for lung fibrosis.
Related Papers:
1.Jiang, D., Liang, J., Juan Fan, Shuang Yu, Suping Chen, Yi Luo, Glenn D. Prestwich, Robert J. Homer, Daniel R. Goldstein, Ruslan Medzhitov, and Paul W. Noble. Regulation of Lung Inflammation and Repair By Toll-like Receptors and Hyaluronan. Nature Medicine. 2005 Nov;11(11):1173-1179. PMID: 16244651.
2.Li, Y., D. Jiang, J. Liang, E. B. Meltzer, A. Gray, R. Miura, L. Wogensen, Y. Yamaguchi, and P. W. Noble. 2011 Unrelenting Lung Fibrosis Requires an Invasive Myofibroblast Phenotype Regulated by Hyaluronan and CD44. J Exp Med. 2011 Jul 4;208(7):1459-71.
3.Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW. {beta}-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix. Science Transl Med. 2011 Mar 16;3(74):74ra23. PMID: 21411739.
4.Noble, P.W., Barkauskas, C.E., and Jiang, D. 2012. Pulmonary fibrosis: patterns and perpetrators. J Clin Invest 122:2756-2762. PMCID 3408732
报告时间：2014年12月8日 9:30 AM
报告地点：703楼五层报告厅
Education
?1984-08, Bachelor of Medicine, Shandong Medical University, Ji’nan, P. R. China
?1996-12, Ph.D., Medical University of Ohio, Toledo, OH
Research Description The current proposal is to investigate the role of β-arrestins in regulating lung inflammation and fibrosis. Specifically, This proposal focuses on elucidating the roles of β-arrestins (βarr1 and βarr2) in regulating lung inflammation and fibrosis and determining the feasibility that targeting β-arrestins as a novel therapeutic approach for lung fibrosis
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