报告题目：Genetic Analysis of Beta Cell Compensation and Decompensation in Zebrafish
报告人：陈文标教授 Vanderbilt University Medical Center
报告时间：2015年7月17日 9:30 AM
报告地点：苏州大学独墅湖校区生科楼703楼一楼东生物钟研究中心会议室
报告人简介：
Dr. Wenbiao Chen, Associate Professor of Vanderbilt University Medical Center. He got his bachelor degree at Hunan Normal University in 1985. In 1993, he obtained his master degree at Washington State University. After obtaining his PhD degree at Oregon Health Sciences University in 1997, he moved to Massachusetts Institute of Technology Center for Cancer research and began his postdoctoral research training until 2001. From 2001 to 2008, Dr. Wenbiao Chen worked as Assistant Scientist in Vollum Institute Oregon Health & Science University. From 2008 to now, he worked as Assistant Professor and Associate Professor in Vanderbilt University Medical Center. Now, Prof. Chen’s group is focused on the compensatory responses of pancreatic a cells and ? cells and their roles in glucose homeostasis and diabetes in zebrafish. His group also developed a high efficiency genome editing and tissue-specific gene knockout systems using CRISPR-Cas9, and has published high-quality papers in Cell, Nature, PNAS, G&D, Nature Genetics, Journal of Neuroscience, and so on.
代表性论文：
1. Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, and Cone RD. (1997). Exocrine glands in dysfunction in MC5-R-deficient mice: Evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 91,789-798.
2. Maddison LA, Chen W. (2012) Nutrient Excess Stimulates Cell Neogenesis in Zebrafish. Diabetes. 61:2517-24.
3. Ni TT, Lu J, Zhu M, Maddison LA, Huskey LC, Boyd K, Ju B, Hesselson D, Zhong TP, Page-McCaw PS, Stainier DY, Chen W. (2012) Conditional control of gene function by an invertible gene trap in zebrafish. PNAS, 109:15389-94.
4. Jao LE, Wente S, Chen W. (2013) Efficient multiplex biallelic zebrafish genome editing using the CRISPR nuclease. PNAS 110(34):13904-9.
5. Yin L, Maddison LA, Li M, Kara N, Varshney GK, LaFave MC, Burgess SM, Patton JG, Chen W. (2015) Multiplex conditional mutagenesis using transgenic expression of Cas9 and sgRNAs. Genetics (Epub, April 6, 2015) (Issue highlight).
(学部办公室)
