报告一：
题目：Chemical Approach for Neural Reprogramming
报告人：Mingliang Zhang PhD
The J David Gladstone Institutes, University of California San Francisco
时间：2016年6月1日（周三）上午8:30-9:30
地点：苏州大学转化医学研究院403号楼3210会议室
报告人简介：With the Bachelor degree from Xiamen University, Dr. Mingliang Zhang took his PhD training in Shanghai Institute of Biochemistry and Cell Biology. Majored in Biochemistry and Molecular Biology, Dr. Zhang’s research at that time was to better understand the mechanism underlying the control of telomere and telomerase, which play the critical role in aging, cancer and genome stability. Dr. Zhang’s collaboration with others has answered long standing questions in telomere field. The serial of works have been published in Nat. Struct. Mol. Biol., Mol. Cell Biol., and Biochem J., and are highly cited and recommended by international professional websites. Dr. Zhang took his postdoctoral training in The J David Gladstone Institutes, where his research is to properly use the chemical tool to better control diverse biological processes, specially the cellular reprogramming toward neural lineage. As the all-chemical approach to cell fate control is challenging, Dr. Zhang and colleagues performed combinatorial chemical screening which led to the identification of a cocktail of nine components (M9) that efficiently reprograms defined fibroblasts into induced neural stem cell-like cells (ciNSLCs). The resulting ciNSLCs closely resemble primary neural stem cells molecularly and functionally. This study not only establishes an effective chemical approach for generating neural stem cells from mouse fibroblasts, but also reveals mechanistic insights into underlying reprogramming processes. This finding provides potential clinical therapeutics for treating neurodegenerative diseases in the future.
报告二：
题目: Mesenchymal stem cells and their clinical implications in tissue regeneration
报告人: 徐亮亮 博士 （香港中文大学）
时间：2016年6月1日（周三）上午9:30-10:30
地点：苏州大学转化医学研究院403号楼3210会议室
报告人简介： 徐亮亮博士，2006年在烟台大学完成本科阶段学习，2009年在中国科学技术大学-广州生物医药与健康研究院完成硕士阶段的学习，主修细胞生物学。2012年获得香港中文大学矫形外科与创伤学博士学位，研究的主要方向为间充质干细胞(MSCs)的分化与调控，以及MSCs在骨折、软骨等组织修复再生中的应用。研究比较了循环MSCs与骨髓来源 MSCs的差别，并从中筛选出三个与迁移、分化相关的基因，并在细胞及动物模型中验证了这些基因的功能，研究成果发表在Int J Biochem Cell Biol.和FASEB Journal等杂志。2012年博士毕业后留校继续从事博士后研究至今，期间与广东医科大学共同研究发现一种中药单体-丹酚酸B可以促进MSCs的成骨分化，该研究成果发布于Int J Biochem Cell Biol.杂志。另外，与团队成员合作发现骨髓MSCs分化及去分化后可以极大地提高MSCs的一些生物学特性，其中Nanog基因启动子的甲基化等表观遗传学的调控在去分化过程中发挥重要作用，该研究成果发表在Sci Rep.杂志。同时发现了一种可以促进MSCs成肌腱细胞分化的小分子化合物，目前尚处于专利申请阶段。在从事博士后研究期间作为负责人主持了国自然青年基金项目一项，并作为主要参与人参加了两项国自然面上基金项目的研究工作。
(科研办公室)
